Editing Oxycodone (section)

==Overdose==
In high doses, [[overdose]]s, or in some persons not tolerant to opioids, oxycodone can cause [[shallow breathing]], [[bradycardia|slowed heart rate]], cold/clammy skin, [[apnea|pauses in breathing]], [[hypotension|low blood pressure]], [[miosis|constricted pupils]], [[circulatory collapse]], [[respiratory arrest]], and death.<ref name="OxyContinInsertUS" />

In 2011, it was the leading cause of drug-related deaths in the U.S.<ref name=CDC2018Death>{{cite web |title=Drugs Most Frequently Involved in Drug Overdose Deaths: United States, 2011–2016 |url=https://www.cdc.gov/nchs/data/nvsr/nvsr67/nvsr67_09-508.pdf |website=CDC |access-date=21 December 2018 |date=12 December 2018 |archive-date=13 December 2018 |archive-url=https://web.archive.org/web/20181213221854/https://www.cdc.gov/nchs/data/nvsr/nvsr67/nvsr67_09-508.pdf |url-status=live }}</ref> However, from 2012 onwards, [[heroin]] and [[fentanyl]] have become more common causes of drug-related deaths.<ref name=CDC2018Death/>

Oxycodone overdose has also been described to cause spinal cord infarction in high doses and [[Brain ischemia|ischemic damage to the brain]], due to prolonged [[Hypoxia (medical)|hypoxia]] from suppressed breathing.<ref>{{cite journal | vauthors = Ntranos A, Shoirah H, Dhamoon MS, Hahn D, Naidich TP, Shin S | title = Clinical Reasoning: A young woman with respiratory failure, hearing loss, and paraplegia | journal = Neurology | volume = 88 | issue = 10 | pages = e78–e84 | date = March 2017 | pmid = 28265044 | doi = 10.1212/WNL.0000000000003684 | doi-access = free }}</ref>