Editing Organ transplantation (section)

=== Domino transplants ===
In people with [[cystic fibrosis]] (CF), where both lungs need to be replaced, it is a technically easier operation with a higher rate of success to replace both the heart and lungs of the recipient with those of the donor. As the recipient's original heart is usually healthy, it can then be transplanted into a second recipient in need of a heart transplant, thus making the person with CF a living heart donor.<ref>{{Cite journal |last1=Yacoub |first1=M. H. |last2=Banner |first2=N. R. |last3=Khaghani |first3=A. |last4=Fitzgerald |first4=M. |last5=Madden |first5=B. |last6=Tsang |first6=V. |last7=Radley-Smith |first7=R. |last8=Hodson |first8=M. |year=1990 |title=Heart-lung transplantation for cystic fibrosis and subsequent domino heart transplantation |journal=The Journal of Heart Transplantation |volume=9 |issue=5 |pages=459–66; discussion 466–67 |pmid=2231084}}</ref>

In a 2016 case at Stanford Medical Center, a woman who was needing a heart-lung transplant had cystic fibrosis which had led to one lung expanding and the other shrinking, thereby displacing her heart.  The second patient who in turn received her heart was a woman with right ventricular dysplasia which had led to a dangerously abnormal rhythm.  The dual operations required three surgical teams, including one to remove the heart and lungs from a recently deceased initial donor.  The two living recipients did well and had an opportunity to meet six weeks after their simultaneous operations.<ref>[https://med.stanford.edu/news/all-news/2016/03/after-rare-procedure-woman-can-hear-her-heart-beat-in-another.html After rare procedure, woman can hear her heart beat in another], Stanford Medicine News Center, Sara Wykes, 29 March 2016.</ref>

Another example of this situation occurs with a special form of liver transplant in which the recipient has [[familial amyloid polyneuropathy]], a disease where the liver slowly produces a [[protein]] that damages other organs. The recipient's liver can then be transplanted into an older person for whom the effects of the disease will not necessarily contribute significantly to mortality.<ref>{{cite web |date=28 January 2003 |title=Mayo Clinic Performs First 'Domino' Transplant in Arizona; Rare Procedure Saves Two Lives at Once, Optimizing Organ Supply |url=http://www.mayoclinic.org/news2003-sct/1622.html |archive-url=https://web.archive.org/web/20030220000729/http://www.mayoclinic.org/news2003-sct/1622.html |archive-date=20 February 2003 |publisher=Mayo Clinic}}</ref>

This term also refers to a series of living donor transplants in which one donor donates to the highest recipient on the waiting list and the transplant center utilizes that donation to facilitate multiple transplants. These other transplants are otherwise impossible due to [[blood type]] or antibody barriers to transplantation. The "[[Good Samaritan]]" kidney is transplanted into one of the other recipients, whose donor in turn donates his or her kidney to an unrelated recipient. This method allows all organ recipients to get a transplant even if their living donor is not a match for them. This further benefits people below any of these recipients on waiting lists, as they move closer to the top of the list for a deceased-donor organ. [[Johns Hopkins Hospital]] in [[Baltimore]] and [[Northwestern University]]'s [[Northwestern Memorial Hospital]] have received significant attention for pioneering transplants of this kind.<ref>{{cite news |last=Blum |first=Karen |date=1 August 2003 |title=Seattle Times Article on domino transplants at Johns Hopkins |url=http://seattletimes.nwsource.com/html/nationworld/2004336130_kidney09.html |archive-url=https://web.archive.org/web/20060614134207/http://www.hopkinshospital.org/health_info/Bladder/Reading/triple_transplant.html |archive-date=14 June 2006 |access-date=17 April 2013 |publisher=Seattletimes.nwsource.com}}</ref><ref>{{cite web |date=8 April 2008 |title=Good Morning America Video on four-way domino 47674874 transplant at Northwestern Memorial Hospital |url=https://abcnews.go.com/GMA/OnCall/story?id=4611316&page=1 |access-date=17 April 2013 |publisher=Abcnews.go.com}}</ref> In February 2012, the last link in a record 60-person domino chain of 30 kidney transplants was completed.<ref>{{cite news |author=Turnbull, Barbara |date=24 February 2012 |title=Kidney transplant chains shorten the wait for wellness |url=http://www.healthzone.ca/health/newsfeatures/article/1136032--kidney-transplant-chains-shorten-the-wait-for-wellness |archive-url=https://web.archive.org/web/20120226092412/http://www.healthzone.ca/health/newsfeatures/article/1136032--kidney-transplant-chains-shorten-the-wait-for-wellness |archive-date=26 February 2012 |access-date=27 February 2012 |publisher=Healthzone.ca}}</ref><ref>{{cite news |author=Laurence, Jeremy |date=27 February 2012 |title=60 lives linked in kidney donor chain |url=http://www.northernstar.com.au/story/2012/02/27/60-lives-linked-kidney-donor-chain/ |access-date=27 February 2012 |newspaper=Northern Star}}</ref>

In May 2023, [[New York Presbyterian Morgan Stanley Children's Hospital]] performed the first domino heart transplantation in a baby, eventually saving two baby girls.<ref>{{cite web |date=8 August 2023 |title=Groundbreaking 'domino' heart surgery at NYC hospital saves lives of 2 baby girls |url=https://www.nbcnewyork.com/news/good-news/groundbreaking-domino-heart-surgery-at-nyc-hospital-saves-lives-of-2-baby-girls/4575196/}}</ref>