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===Other effects=== There is anecdotal evidence that the use of nitrox reduces post-dive fatigue,<ref name="Scubaboard Poll" /> particularly in older and or obese divers; however a double-blind study to test this found no statistically significant reduction in reported fatigue.<ref name=Brubakk/><ref name="Harris et al 2003" /> There was, however, some suggestion that post-dive fatigue is due to sub-clinical decompression sickness (DCS) (i.e. micro bubbles in the blood insufficient to cause symptoms of DCS); the fact that the study mentioned was conducted in a dry chamber with an ideal decompression profile may have been sufficient to reduce sub-clinical DCS and prevent fatigue in both nitrox and air divers. In 2008, a study was published using wet divers at the same depth no statistically significant reduction in reported fatigue was seen.<ref name=AAUS2008 /> Further studies with a number of different dive profiles, and also different levels of exertion, would be necessary to fully investigate this issue. For example, there is much better scientific evidence that breathing high-oxygen gases increases exercise tolerance, during aerobic exertion.<ref name="Anderson 2015" /> Though even moderate exertion while breathing from the regulator is a relatively uncommon occurrence in recreational scuba, as divers usually try to minimize it in order to conserve gas, episodes of exertion while regulator-breathing do occasionally occur in recreational diving. Examples are surface-swimming a distance to a boat or beach after surfacing, where residual "safety" cylinder gas is often used freely, since the remainder will be wasted anyway when the dive is completed, and unplanned contingencies due to currents or buoyancy problems. It is possible that these so-far un-studied situations have contributed to some of the positive reputation of nitrox. A 2010 study using [[critical flicker fusion frequency]] and perceived fatigue criteria found that diver alertness after a dive on nitrox was significantly better than after an air dive.<ref name="Lafere et al 2010" />
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