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===Other=== ; Omega-3 fatty acids : It is also conjectured that [[omega-3 fatty acid]]s may have a mood stabilizing effect.<ref name=pmid11152679>{{cite journal |vauthors=Mirnikjoo B, Brown SE, Kim HF, Marangell LB, Sweatt JD, Weeber EJ |title=Protein kinase inhibition by omega-3 fatty acids |journal=J. Biol. Chem. |volume=276 |issue=14 |pages=10888β96 |date=April 2001 |pmid=11152679 |doi=10.1074/jbc.M008150200 |doi-access=free }}</ref> Compared with placebo, omega-3 fatty acids appear better able to augment known mood stabilizers in reducing depressive (but perhaps not manic) symptoms of bipolar disorder; additional trials would be needed to establish the effects of omega-3 fatty acids alone.<ref>{{Cite journal | doi = 10.1111/j.1399-5618.2005.00250.x | pmid = 16225556 | title = Newer treatment studies for bipolar depression | year = 2005 | last1 = Gao | first1 = K. | last2 = Calabrese | first2 = J. R. | journal = Bipolar Disorders | volume = 7 | issue = s5 | pages = 13β23 }}</ref> ; Levothyroxine : It is known that even subclinical [[hypothyroidism]] can blunt a patient's response to both mood stabilizers and antidepressants. Furthermore, preliminary research into the use of thyroid augmentation in patients with refractory and rapid-cycling bipolar disorder has been positive, showing a slowing in cycle frequency and reduction in symptoms. Most studies have been conducted on an open-label basis. One large, controlled study of 300 mcg daily dose of [[Levothyroxine|levothyroxine (T<sub>4</sub>)]] found it superior to placebo for this purpose. In general, studies have shown T4 to be well tolerated and to show efficacy even in patients without overt hypothyroidism.<ref>AMA Chakrabarti S. Thyroid Functions and Bipolar Affective Disorder. Journal of Thyroid Research. 2011;2011:306367. doi:10.4061/2011/306367. MLA Chakrabarti, Subho. "Thyroid Functions and Bipolar Affective Disorder". Journal of Thyroid Research 2011 (2011): 306367. PMC. Web. 19 May 2017. APA Chakrabarti, S. (2011). Thyroid Functions and Bipolar Affective Disorder. Journal of Thyroid Research, 2011, 306367. http://doi.org/10.4061/2011/306367</ref> Hypothyrodism is common among bipolar patients regardless of the mood stabilizer used.<ref>{{cite journal | vauthors = Lambert CG, Mazurie AJ, Lauve NR, Hurwitz NG, Young SS, Obenchain RL, Hengartner NW, Perkins DJ, Tohen M, Kerner B | title = Hypothyroidism risk compared among nine common bipolar disorder therapies in a large US cohort | journal = Bipolar Disorders | volume = 18 | issue = 3 | pages = 247β260 | date = May 2016 | pmid = 27226264 | pmc = 5089566 | doi = 10.1111/bdi.12391 }}</ref>
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