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===Matrix=== {{Main|Mitochondrial matrix}} The matrix is the space enclosed by the inner membrane. It contains about 2/3 of the total proteins in a mitochondrion.<ref name="Alberts-2005"/> The matrix is important in the production of ATP with the aid of the ATP synthase contained in the inner membrane. The matrix contains a highly concentrated mixture of hundreds of enzymes, special mitochondrial [[ribosomes]], [[tRNA]], and several copies of the [[mitochondrial DNA]] [[genome]]. Of the enzymes, the major functions include oxidation of [[pyruvate]] and [[fatty acids]], and the [[citric acid cycle]].<ref name="Alberts-2005" /> The DNA molecules are packaged into nucleoids by proteins, one of which is [[TFAM]].<ref>{{cite journal | vauthors = Bogenhagen DF | title = Mitochondrial DNA nucleoid structure | journal = Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | volume = 1819 | issue = 9β10 | pages = 914β920 | date = September 2012 | pmid = 22142616 | doi = 10.1016/j.bbagrm.2011.11.005 }}</ref>
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