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===Super resolution microscopes=== {{Main|Super-resolution microscopy|Microscopy#Sub-diffraction techniques}} Much current research (in the early 21st century) on optical microscope techniques is focused on development of [[superresolution]] analysis of fluorescently labelled samples. [[Microscopy#Structured illumination|Structured illumination]] can improve resolution by around two to four times and techniques like [[stimulated Emission Depletion microscopy|stimulated emission depletion (STED) microscopy]] are approaching the resolution of electron microscopes.<ref>{{Cite web |title=The Nobel Prize in Chemistry 2014 β Scientific Background |url=https://www.nobelprize.org/nobel_prizes/chemistry/laureates/2014/advanced-chemistryprize2014.pdf |archive-url=https://web.archive.org/web/20180320230951/https://www.nobelprize.org/nobel_prizes/chemistry/laureates/2014/advanced-chemistryprize2014.pdf |archive-date=2018-03-20 |access-date=2018-03-20 |website=www.nobelprize.org}}</ref> This occurs because the diffraction limit is occurred from light or excitation, which makes the resolution must be doubled to become super saturated. Stefan Hell was awarded the 2014 Nobel Prize in Chemistry for the development of the STED technique, along with Eric Betzig and William Moerner who adapted fluorescence microscopy for single-molecule visualization.<ref>{{Cite web|url=https://www.nobelprize.org/nobel_prizes/chemistry/laureates/2014/press.html|title=The Nobel Prize in Chemistry 2014|website=www.nobelprize.org|access-date=2018-03-20}}</ref>
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