Editing Mescaline (section)

==Interactions==
{{See also|Psychedelic drug#Interactions|Trip killer#Serotonergic psychedelic antidotes}}

The [[serotonin]] [[5-HT2A receptor|5-HT<sub>2A</sub> receptor]] [[receptor antagonist|antagonist]] [[ketanserin]] has been found to block the psychoactive effects of mescaline.<ref name="KlaiberSchmidBecker2024" /><ref name="KlaiberBeckerStraumann2024">{{cite journal | vauthors=Klaiber A, Becker AM, Straumann I, Thomann J, Luethi D, Schmid Y, Liechti ME | title=Supplementum 276: Abstracts of the 8th Annual Spring Congress of the Swiss Society of General Internal Medicine: P162. Acute subjective effects and pharmacokinetics of different doses of mescaline | journal=Swiss Medical Weekly | volume=154 | issue=5 | date=21 May 2024 | issn=1424-3997 | doi=10.57187/s.3896 | doi-access=free | pages=126S | pmid=38771022 }}</ref>

It is unclear whether mescaline is [[drug metabolism|metabolized]] by [[monoamine oxidase]] (MAO) [[enzyme]]s<ref name="Dinis-OliveiraPereiradaSilva2019" /><ref name="KapadiaFayez1970" /> or whether [[monoamine oxidase inhibitor]]s (MAOIs) might increase the effects of mescaline.<ref name="Ott1996">{{cite journal | vauthors = Ott J | title = Pharmahuasca: On Phenethylamines and Potentiation | journal = MAPS Newsletter | volume = 6 | issue = 3 | pages = 32–35 | url = https://maps.org/wp-content/uploads/1996/04/v06n3_34-37_pharmauhsca.pdf | quote = [...] there is circumstantial evidence for traditional use of ayahuasca containing mescaline and/or other β-phenethylamines in Amazonian Peru. [...] preliminary human bioassays suggest that the β-carboline harmaline might in fact potentiate mescaline - low doses of 60 and 100 mg mescaline hydrochloride, corresponding to 51 and 86 mg base or 0.78 and 1.32 mg/kg respectively, were decidedly psychoactive. The combination of mescaline or mescaline-containing cacti with β-carbolines has been dubbed peyohuasca.(5,18)}}</ref> However, there are preliminary reports that [[harmala alkaloid]]s may potentiate mescaline, and the combination of mescaline or mescaline-containing cacti with harmala alkaloids has been referred to as "peyohuasca".<ref name="Ott1996" />