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===Nervous system=== [[Dural ectasia]], the weakening of the connective tissue of the dural sac encasing the [[spinal cord]], can result in a loss of [[quality of life]]. It can be present for a long time without producing any noticeable symptoms. Symptoms that can occur are lower back pain, leg pain, abdominal pain, other neurological symptoms in the lower extremities, or headaches{{spnd}}symptoms which usually diminish when lying flat. On [[X-ray]], however, dural ectasia is not often visible in the early stages. A worsening of symptoms might warrant an [[MRI]] of the lower spine. Dural ectasia that has progressed to this stage would appear in an MRI as a dilated pouch wearing away at the [[lumbar vertebrae]].<ref name="mayo-gen">{{cite web|url=http://www.mayoclinic.com/health/marfan-syndrome/DS00540/DSECTION=2|title=Marfan Syndrome|access-date=January 12, 2007|publisher=Mayo Clinic|url-status=live|archive-url=https://web.archive.org/web/20070110144623/http://mayoclinic.com/health/marfan-syndrome/DS00540/DSECTION%3D2|archive-date=January 10, 2007}}</ref> Other spinal issues associated with MFS include [[degenerative disc disease]], spinal [[cyst]]s, and [[dysautonomia|dysfunction of the autonomic nervous system]].{{citation needed|date=September 2021}}
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