Editing Locked-in syndrome (section)

==Prognosis==
It is extremely rare for any significant motor function to return, with the majority of locked-in syndrome patients never regaining motor control. However, some people with the condition continue to live for extended periods of time, reported up to a few decades<ref name=esquire1>{{cite news|url=http://www.esquire.com/features/unspeakable-odyssey-motionless-boy-1008 |title=The Unspeakable Odyssey of the Motionless Boy|author= Joshua Foer|work= Esquire |date= October 2, 2008}}</ref><ref>Piotr Kniecicki "An art of graceful dying". Clitheroe: Łukasz Świderski, 2014, s. 73. {{ISBN|978-0-9928486-0-6}}</ref> while in exceptional cases, like that of Kerry Pink,<ref name=BBCnews>{{cite news|url=https://www.bbc.co.uk/news/health-10985836 |title=I recovered from locked-in syndrome|work= BBC Radio 5 Live|author= Stephen Nolan|date= August 16, 2010}}</ref> Gareth Shepherd,<ref name=Dailyecho>{{cite news|url=https://www.dailyecho.co.uk/news/14866880.he-crashed-his-motorbike-and-had-a-stroke-but-hampshire-man-gareth-shepherd-is-back-on-his-feet |title=He crashed his motorbike and had a stroke - but Hampshire man Gareth Shepherd is back on his feet|work=Daily Echo|date=November 8, 2016}}</ref>{{Failed verification|date=December 2024|talk=Gareth Shepherd|reason=Article references Shepherd being comatose, but not having Locked-in syndrome}} Jacob Haendel,<ref name=YouTube>{{cite news|url=https://www.youtube.com/channel/UCpoJxQNKSybRuSXEEuQ0cNA |title=Jacob Haendel Recovery Channel|work= Jacob Handel Recovery|date= June 29, 2020}}</ref> Kate Allatt,<ref name=BBCnews2>{{cite news|url=https://www.bbc.co.uk/news/health-17363584 |title=Woman's recovery from 'locked-in' syndrome|work= BBC News|date= March 14, 2012}}</ref> and Jessica Wegbrans,<ref name=Flinkberoerd>{{cite news|url=https://www.flinkberoerd.nl |title=Het gevecht tegen locked-in|work= Flinkberoerd|date=April 23, 2022}}</ref> a near-full recovery may be achieved with intensive physical therapy. These substantial recoveries in motor movement are thought to be due to potential reorganization of the descending spinal tract pathways. Of those that see improvements in motor functioning, it is thought to be more likely to occur in nonvascular cases of locked-in syndrome compared to vascular patients, as well as distal motor functions being more likely to recover than other facial muscles.<ref>{{Cite journal |last1=Patterson |first1=J R |last2=Grabois |first2=M |date=July 1986 |title=Locked-in syndrome: a review of 139 cases. |url=https://www.ahajournals.org/doi/10.1161/01.STR.17.4.758 |journal=Stroke |language=en |volume=17 |issue=4 |pages=758–764 |doi=10.1161/01.STR.17.4.758 |pmid=3738962 |issn=0039-2499}}</ref><ref>{{Cite journal |last1=Richard |first1=I. |last2=Péreon |first2=Y. |last3=Guiheneu |first3=P. |last4=Nogues |first4=B. |last5=Perrouin-Verbe |first5=B. |last6=Mathe |first6=J. F. |date=November 1995 |title=Persistence of distal motor control in the locked in syndrome. Review of 11 patients |url=https://www.nature.com/articles/sc1995135 |journal=Spinal Cord |language=en |volume=33 |issue=11 |pages=640–646 |doi=10.1038/sc.1995.135 |pmid=8584298 |issn=1476-5624}}</ref>

Although depression has been diagnosed in a subset of patients with locked-in syndrome, literature suggests that many patients still report a significantly high quality life over time and that they are happy, with negative respondents having received their diagnosis relatively recently.<ref>{{Cite journal |last1=Bruno |first1=Marie-Aurélie |last2=Bernheim |first2=Jan L |last3=Ledoux |first3=Didier |last4=Pellas |first4=Frédéric |last5=Demertzi |first5=Athena |last6=Laureys |first6=Steven |date=2011 |title=A survey on self-assessed well-being in a cohort of chronic locked-in syndrome patients: happy majority, miserable minority |journal=BMJ Open |language=en |volume=1 |issue=1 |pages=e000039 |doi=10.1136/bmjopen-2010-000039 |pmid=22021735 |pmc=3191401 |issn=2044-6055}}</ref> This content may derive from their retained consciousness that allows the individual to still experience life and participate in activities they enjoy as well as have obligations in their home life. It is true to say that the degree to which a patient can do is dependent on how severe their symptomology is, but many individuals report leaving the house more than once a month, to where there was ultimately no differences in quality of life between a person with locked-in syndrome and a studied healthy control.<ref>{{Cite journal |last1=Doble |first1=Jennifer E. |last2=Haig |first2=Andrew J. |last3=Anderson |first3=Christopher |last4=Katz |first4=Richard |date=September–October 2003 |title=Impairment, Activity, Participation, Life Satisfaction, and Survival in Persons With Locked-In Syndrome for Over a Decade: Follow-Up on a Previously Reported Cohort |url=https://journals.lww.com/headtraumarehab/abstract/2003/09000/impairment,_activity,_participation,_life.5.aspx |journal=The Journal of Head Trauma Rehabilitation |language=en-US |volume=18 |issue=5 |pages=435–444 |doi=10.1097/00001199-200309000-00005 |pmid=12973273 |issn=0885-9701}}</ref><ref>{{Cite journal |last1=Rousseau |first1=Marie-Christine |last2=Pietra |first2=Stephane |last3=Nadji |first3=Mohammed |last4=Billette de Villemeur |first4=Thierry |date=November 2013 |title=Evaluation of Quality of Life in Complete Locked-In Syndrome Patients |url=https://www.liebertpub.com/doi/10.1089/jpm.2013.0120 |journal=Journal of Palliative Medicine |volume=16 |issue=11 |pages=1455–1458 |doi=10.1089/jpm.2013.0120 |pmid=24215251 |issn=1096-6218}}</ref>