Editing Isocyanate (section)

=== Rearrangement reactions ===
Isocyanates are common intermediates in the synthesis of primary amines via [[hydrolysis]]:
* [[Hofmann rearrangement]], a reaction in which a primary [[amide]] is treated with a [[Oxidizing agent|strong oxidizer]] such as sodium [[hypobromite]]<ref>http://alpha.chem.umb.edu/chemistry/orgchem/CH20Handout.pdf {{Webarchive|url=https://web.archive.org/web/20060911031125/http://alpha.chem.umb.edu/chemistry/orgchem/CH20Handout.pdf |date=2006-09-11 }}, Ch20Handout, University of Massachusetts Boston</ref><ref>{{cite book|last1= Mann |first1= F. G. |last2= Saunders |first2= B. C.|title=Practical Organic Chemistry, 4th Ed.|year=1960|publisher=Longman|location=London|isbn=978-0-582-44407-2|page=128|url=https://www.scribd.com/doc/46973684/Practical-Organic-Chemistry-Frederick-George-Mann}}</ref><ref>{{cite book|last=Cohen|first=Julius|title=Practical Organic Chemistry 2nd Ed.|year=1900|publisher=Macmillan and Co., Limited|location=London|page=[https://archive.org/details/practicalorgani00cohegoog/page/n90 72]|url=https://archive.org/details/practicalorgani00cohegoog|quote=Practical Organic Chemistry Cohen Julius.}}</ref> or [[lead tetraacetate]]<ref>{{cite journal|author1=Baumgarten, Henry |author2=Smith, Howard |author3=Staklis, Andris |title=Reactions of amines. XVIII. Oxidative rearrangement of amides with lead tetraacetate|journal=The Journal of Organic Chemistry|year=1975|volume=40|issue=24|pages=3554–3561|doi=10.1021/jo00912a019}}</ref> to form an isocyanate intermediate.