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===Incubation period=== The exact length of [[incubation period|time between infection and symptoms]] is unclear. A review of the literature made an estimate of 33β49 days.<ref name=Richardson2001>{{cite journal|last=Richardson|first=M|author2=Elliman, D |author3=Maguire, H |author4=Simpson, J |author5= Nicoll, A |title=Evidence base of incubation periods, periods of infectiousness and exclusion policies for the control of communicable diseases in schools and preschools|journal=The Pediatric Infectious Disease Journal|date=April 2001|volume=20|issue=4|pages=380β91|pmid=11332662|doi=10.1097/00006454-200104000-00004|s2cid=7700827}}</ref> In adolescents and young adults, symptoms are thought to appear around 4β6 weeks after initial infection.<ref name=Harrison>{{cite book |last=Cohen|first=Jeffrey I.| veditors=Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscalzo J |title=Harrison's principles of internal medicine |pages=380β91|publisher=McGraw-Hill Medical Publishing Division |location=New York |year=2008 |edition=17th |chapter=Epstein-Barr Infections, Including Infectious Mononucleosis|isbn=978-0-07-146633-2}}</ref> Onset is often gradual, though it can be abrupt.<ref name=Odumade2011>{{cite journal | vauthors = Odumade OA, Hogquist KA, Balfour HH | title = Progress and problems in understanding and managing primary Epstein-Barr virus infections | journal = Clin. Microbiol. Rev. | volume = 24 | issue = 1 | pages = 193β209 | date = January 2011 | pmid = 21233512 | pmc = 3021204 | doi = 10.1128/CMR.00044-10 }}</ref> The main symptoms may be [[prodrome|preceded]] by 1β2 weeks of fatigue, feeling unwell and body aches.<ref name=Harrison/>
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