Editing Haematoxylin (section)

===Shortages and possible alternatives===
During [[World War I]], the late 1920s, [[World War II]], the early 1970s (summer 1973<ref name="Lillie, 1974" />) and in 2008, there were shortages of haematoxylin due to interruptions in its extraction from logwood.<ref name="Dapson et al., 2010" /> These shortages prompted a search for alternative nuclear stains.<ref name="Lillie, 1974" /><ref name="Dapson et al., 2010" /> Several synthetic dyes have been recommended as replacements, notably celestine blue (CI 51050),<ref name="Dapson et al., 2010" /> [[Gallocyanin stain|gallocyanine]]<ref name="Titford, 2005" /><ref name="Llewellyn, 2009" /> (CI 51030), gallein<ref name="Dapson et al., 2010" /> (CI 45445) and [[Cyanine#Nucleic Acid Labeling|eriochrome cyanine R]]<ref name="Dapson et al., 2010" /><ref name="Llewellyn, 2009" /> also called chromoxane cyanine R and solochrome cyanine (CI 43820). All four have Fe(III) as the [[mordant]]. An alternative is the aluminium complex of oxidized [[brazilin]], which differs from haematoxylin by only one hydroxyl group. A replacement stain for haematoxylin in [[H&E|H&E staining]] must also not disrupt the ability of histologists and pathologists,<ref name="Dapson and Horobin, 2009" /> who have spent years of training with H&E stained slides, to examine the slides and make [[diagnoses|medical diagnoses]].<ref name="Titford, 2005" /> None of proposed replacement stains have been widely adopted.<ref name="Dapson and Horobin, 2009" /><ref name="Titford, 2005" />