Editing Gout (section)

===Medication===
[[Diuretic]]s have been associated with attacks of gout, but a low dose of [[hydrochlorothiazide]] does not seem to increase risk.<ref name=CFP09/> Other medications that increase the risk include [[Niacin (substance)|niacin]], [[aspirin]] (acetylsalicylic acid), [[ACE inhibitor]]s, [[angiotensin receptor blocker]]s, [[beta blocker]]s, [[ritonavir]], and [[pyrazinamide]].<ref name="Dalbeth2016"/><ref name=Nature2009/> The [[immunosuppressive drug]]s [[ciclosporin]] and [[tacrolimus]] are also associated with gout,<ref name=Lancet2010/> the former more so when used in combination with hydrochlorothiazide.<ref>{{cite book |editor1-first=Gary S. |editor1-last=Firestein |editor2-first=Ralph C. |editor2-last=Budd |editor3-first=Edward D. |editor3-last=Harris |editor4-first= Iain B. |editor4-last=McInnes |editor5-first=Shaun |editor5-last=Ruddy |editor6-first=John S. |editor6-last=Sergent |title=Kelley's Textbook of Rheumatology |edition=8th |year=2008 |publisher=Elsevier |isbn=978-1-4160-4842-8 |chapter=Chapter 87: Gout and Hyperuricemia}}</ref> Hyperuricemia may be induced by excessive use of Vitamin D supplements. Levels of serum uric acid have been positively associated with 25(OH) D. The incidence of hyperuricemia increased 9.4% for every 10 nmol/L increase in 25(OH) D (P < 0.001).<ref>{{cite journal |last1=Chen |first1=Yingchao |date=2020 |title=Association between serum vitamin D and uric acid in the eastern Chinese population: a population-based cross-sectional study. |url=https://rdcu.be/cHtkQ |journal=BMC Endocr Disord |volume=20 |issue=79 |page=79 |doi=10.1186/s12902-020-00560-1 |pmid=32493273 |pmc=7268462 |access-date=21 June 2021 |doi-access=free |archive-date=10 July 2024 |archive-url=https://web.archive.org/web/20240710063618/https://www.biomedcentral.com/epdf/10.1186/s12902-020-00560-1?sharing_token=2cW1CJCCbuDOmSgFjaRPuG_BpE1tBhCbnbw3BuzI2RPh6v_muYveTL-poMvfpyCalHaXszrUOCBZ-NGpeESiL0L0YQKZPY0oqu5huqTmGuIDlN9g0iJL3O3BCtGRpPDqRBNWnHFNYtFJW0A94ysz7f5HqEtewOugX5HVi3vR3AE%3D |url-status=live }}</ref>