Editing Folate (section)

===Stroke===
The [[absolute risk]] of stroke with supplementation decreases from 4.4% to 3.8% (a 10% decrease in relative risk).<ref name=Li2016/> Two other meta-analyses reported a similar decrease in relative risk.<ref name=Tian2017>{{cite journal |vauthors=Tian T, Yang KQ, Cui JG, Zhou LL, Zhou XL |s2cid=3500861 |title=Folic Acid Supplementation for Stroke Prevention in Patients With Cardiovascular Disease |journal=Am. J. Med. Sci. |volume=354 |issue=4 |pages=379–387 |date=October 2017 |pmid=29078842 |doi=10.1016/j.amjms.2017.05.020 }}</ref><ref name=Zhao2017>{{cite journal |vauthors=Zhao M, Wu G, Li Y, Wang X, Hou FF, Xu X, Qin X, Cai Y |s2cid=325155 |title=Meta-analysis of folic acid efficacy trials in stroke prevention: Insight into effect modifiers |journal=Neurology |volume=88 |issue=19 |pages=1830–1838 |date=May 2017 |pmid=28404799 |doi=10.1212/WNL.0000000000003909 }}</ref> Two of these three were limited to people with pre-existing cardiovascular disease or coronary heart disease.<ref name=Li2016/><ref name=Tian2017/> The beneficial result may be associated with lowering circulating [[homocysteine]] concentration, as stratified analysis showed that risk was reduced more when there was a larger decrease in homocysteine.<ref name=Li2016/><ref name=Tian2017/> The effect was also larger for the studies that were conducted in countries that did not have mandatory grain folic acid fortification.<ref name=Tian2017/><ref name=Zhao2017/> The beneficial effect was larger in the subset of trials that used a lower folic acid supplement compared to higher.<ref name=Tian2017/><ref name=Zhao2017/>