Editing Fibroblast (section)

===Tumour mediation===
Fibroblasts, like [[Cancer-associated fibroblast |tumor-associated host fibroblasts]] (TAF), play a crucial role in immune regulation through TAF-derived ECM components and modulators. TAF are known to be significant in the inflammatory response as well as immune suppression in tumors. TAF-derived ECM components cause alterations in ECM composition and initiate the ECM remodeling.<ref name=":0">{{cite journal | vauthors = Silzle T, Randolph GJ, Kreutz M, Kunz-Schughart LA | title = The fibroblast: sentinel cell and local immune modulator in tumor tissue | journal = International Journal of Cancer | volume = 108 | issue = 2 | pages = 173–180 | date = January 2004 | pmid = 14639599 | doi = 10.1002/ijc.11542 | s2cid = 10936034 | doi-access =  }}</ref> ECM remodeling is described as changes in the ECM as a result of [[enzyme]] activity which can lead to degradation of the ECM. Immune regulation of tumors is largely determined by ECM remodeling because the ECM is responsible for regulating a variety of functions, such as proliferation, differentiation, and morphogenesis of vital organs.<ref>{{cite journal | vauthors = Bonnans C, Chou J, Werb Z | title = Remodelling the extracellular matrix in development and disease | journal = Nature Reviews. Molecular Cell Biology | volume = 15 | issue = 12 | pages = 786–801 | date = December 2014 | pmid = 25415508 | pmc = 4316204 | doi = 10.1038/nrm3904 }}</ref> In many tumor types, especially those related to the epithelial cells, ECM remodeling is common. Examples of TAF-derived ECM components include Tenascin and Thrombospondin-1 (TSP-1), which can be found in sites of chronic inflammation and carcinomas, respectively.<ref name=":0" />

Immune regulation of tumors can also occur through the TAF-derived modulators. Although these modulators may sound similar to the TAF-derived ECM components, they differ in the sense that they are responsible for the variation and turnover of the ECM. Cleaved ECM molecules can play a critical role in immune regulation. Proteases like matrix [[Metalloproteinase|metalloproteineases]] and the uPA system are known to cleave the ECM. These proteases are derived from fibroblasts.<ref name=":0" />