Editing Enzyme (section)

==== "Lock and key" model ====
To explain the observed specificity of enzymes, in 1894 [[Hermann Emil Fischer|Emil Fischer]] proposed that both the enzyme and the substrate possess specific complementary geometric shapes that fit exactly into one another.<ref>{{cite journal | vauthors = Fischer E | year = 1894 | title = Einfluss der Configuration auf die Wirkung der Enzyme | language = de | trans-title = Influence of configuration on the action of enzymes | journal=Berichte der Deutschen Chemischen Gesellschaft zu Berlin | volume = 27 | issue = 3 | pages = 2985–93 | url = http://gallica.bnf.fr/ark:/12148/bpt6k90736r/f364.chemindefer|doi=10.1002/cber.18940270364 }} From page 2992: ''"Um ein Bild zu gebrauchen, will ich sagen, dass Enzym und Glucosid wie Schloss und Schlüssel zu einander passen müssen, um eine chemische Wirkung auf einander ausüben zu können."'' (To use an image, I will say that an enzyme and a glucoside [i.e., glucose derivative] must fit like a lock and key, in order to be able to exert a chemical effect on each other.)</ref> This is often referred to as "the lock and key" model.<ref name="Stryer_2002" />{{rp|8.3.2}} This early model explains enzyme specificity, but fails to explain the stabilization of the transition state that enzymes achieve.<ref name="Cooper_2000">{{cite book | author = Cooper GM | title = The Cell: a Molecular Approach | date = 2000 | publisher = ASM Press | location = Washington (DC ) | isbn = 0-87893-106-6 | edition = 2nd | chapter = Chapter 2.2: The Central Role of Enzymes as Biological Catalysts | chapter-url = https://www.ncbi.nlm.nih.gov/books/NBK9921/ | url-access = registration | url = https://archive.org/details/cell00geof }}</ref>