Editing Electroporation (section)

===H-FIRE===
High-frequency irreversible electroporation (H-FIRE) uses electrodes to apply bipolar bursts of electricity at a high frequency, as opposed to unipolar bursts of electricity at a low frequency. This type of procedure has the same tumor ablation success as N-TIRE. However, it has one distinct advantage: H-FIRE does not cause muscle contraction in the patient, and therefore, there is no need for a paralytic agent.<ref>{{cite journal | vauthors = Arena CB, Sano MB, Rossmeisl JH, Caldwell JL, Garcia PA, Rylander MN, Davalos RV | title = High-frequency irreversible electroporation (H-FIRE) for non-thermal ablation without muscle contraction | journal = BioMedical Engineering OnLine | volume = 10 | pages = 102 | date = November 2011 | pmid = 22104372 | pmc = 3258292 | doi = 10.1186/1475-925X-10-102 | doi-access = free }}</ref> Furthermore, H-FIRE has been demonstrated to produce more predictable ablations due to the lesser difference in the electrical properties of tissues at higher frequencies.<ref>{{cite journal | vauthors = Bhonsle SP, Arena CB, Sweeney DC, Davalos RV | title = Mitigation of impedance changes due to electroporation therapy using bursts of high-frequency bipolar pulses | journal = BioMedical Engineering OnLine | volume = 13 | pages = S3 | date = 27 August 2015 | issue = Suppl 3 | pmid = 26355870 | pmc =4565149 | doi = 10.1186/1475-925X-14-S3-S3 | doi-access = free }}</ref>