Editing Chloramphenicol (section)

===Bone marrow suppression===
Chloramphenicol may cause [[bone marrow suppression]] during treatment; this is a direct toxic effect of the drug on human [[mitochondria]].<ref name="pmid2486534">{{cite journal | vauthors = Yunis AA | title = Chloramphenicol toxicity: 25 years of research | journal = The American Journal of Medicine | volume = 87 | issue = 3N | pages = 44N–48N | date = September 1989 | pmid = 2486534 }}</ref> This effect manifests first as a fall in [[hemoglobin]] levels, which occurs quite predictably once a cumulative dose of 20&nbsp;g has been given. The anaemia is fully reversible once the drug is stopped and does not predict future development of aplastic anaemia. Studies in mice have suggested existing marrow damage may compound any marrow damage resulting from the toxic effects of chloramphenicol.<ref>{{cite journal | vauthors = Morley A, Trainor K, Remes J | title = Residual marrow damage: possible explanation for idiosyncrasy to chloramphenicol | journal = British Journal of Haematology | volume = 32 | issue = 4 | pages = 525–531 | date = April 1976 | pmid = 1259934 | doi = 10.1111/j.1365-2141.1976.tb00955.x | s2cid = 40234293 }}</ref>