Editing Cellular differentiation (section)

=== Inductive signaling ===
Signal induction refers to cascades of signaling events, during which a cell or tissue signals to another cell or tissue to influence its developmental fate.<ref name=Rudel/> Yamamoto and Jeffery<ref name=Yamamoto>Yamamoto Y and WR Jeffery; Central role for the lens in cave fish eye degeneration. '' Science '' 289 (5479), 631-633, 2000 {{cite journal | vauthors = Yamamoto Y, Jeffery WR | title = Central role for the lens in cave fish eye degeneration | journal = Science | volume = 289 | issue = 5479 | pages = 631–633 | date = July 2000 | pmid = 10915628 | doi = 10.1126/science.289.5479.631 | bibcode = 2000Sci...289..631Y }}</ref> investigated the role of the lens in eye formation in cave- and surface-dwelling fish, a striking example of induction.<ref name=Rudel/> Through reciprocal transplants, Yamamoto and Jeffery<ref name=Yamamoto/> found that the lens vesicle of surface fish can induce other parts of the eye to develop in cave- and surface-dwelling fish, while the lens vesicle of the cave-dwelling fish cannot.<ref name=Rudel/>