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=== Comorbid conditions === People with bipolar disorder often have other co-existing psychiatric conditions such as [[anxiety]] (present in about 71% of people with bipolar disorder), substance abuse (56%), [[personality disorders]] (36%) and [[attention deficit hyperactivity disorder]] (10β20%) which can add to the burden of illness and worsen the prognosis.<ref name="Carvalho">{{cite journal |vauthors=Carvalho AF, Firth J, Vieta E |title=Bipolar Disorder |journal=N. Engl. J. Med. |volume=383 |issue=1 |pages=58β66 |date=July 2020 |pmid=32609982 |doi=10.1056/NEJMra1906193 |s2cid=220309576 }}</ref> Certain medical conditions are also more common in people with bipolar disorder as compared to the general population. This includes increased rates of [[metabolic syndrome]] (present in 37% of people with bipolar disorder), [[migraine headaches]] (35%), [[obesity]] (21%) and [[type 2 diabetes]] (14%).<ref name="Carvalho" /> This contributes to a risk of death that is two times higher in those with bipolar disorder as compared to the general population.<ref name="Carvalho" /> [[Hypothyroidism]] is also common regardless of drug choice.<ref>{{cite journal | vauthors = Lambert CG, Mazurie AJ, Lauve NR, Hurwitz NG, Young SS, Obenchain RL, Hengartner NW, Perkins DJ, Tohen M, Kerner B | title = Hypothyroidism risk compared among nine common bipolar disorder therapies in a large US cohort | journal = Bipolar Disorders | volume = 18 | issue = 3 | pages = 247β260 | date = May 2016 | pmid = 27226264 | pmc = 5089566 | doi = 10.1111/bdi.12391 }}</ref> [[Substance use disorder]] is a common comorbidity in bipolar disorder; the subject has been widely reviewed.<ref>{{cite journal | vauthors = Cassidy F, Ahearn EP, Carroll BJ | title = Substance abuse in bipolar disorder | journal = Bipolar Disorders | volume = 3 | issue = 4 | pages = 181β188 | date = August 2001 | pmid = 11552957 | doi = 10.1034/j.1399-5618.2001.30403.x }}</ref>{{update inline|date=August 2022}}<ref>{{Cite journal |last1=Preuss |first1=Ulrich W. |last2=Schaefer |first2=Martin |last3=Born |first3=Christoph |last4=Grunze |first4=Heinz |date=2021-11-17 |title=Bipolar Disorder and Comorbid Use of Illicit Substances |journal=Medicina |language=en |volume=57 |issue=11 |pages=1256 |doi=10.3390/medicina57111256 |doi-access=free |pmid=34833474 |pmc=8623998 |issn=1648-9144}}</ref><ref>{{cite journal | vauthors = Messer T, Lammers G, MΓΌller-Siecheneder F, Schmidt RF, Latifi S | title = Substance abuse in patients with bipolar disorder: A systematic review and meta-analysis | journal = Psychiatry Research | volume = 253 | pages = 338β350 | date = July 2017 | pmid = 28419959 | doi = 10.1016/j.psychres.2017.02.067 | s2cid = 24177245 }}</ref>
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