Editing Apoptosis (section)

==== Fas pathway ====
{{main|Activation-induced cell death}}

The [[fas receptor]]  (First apoptosis signal) – (also known as ''Apo-1'' or ''CD95'') is a [[transmembrane protein]] of the TNF family which binds the [[FAS ligand|Fas ligand]] (FasL).<ref name="fas"/> The interaction between Fas and FasL results in the formation of the ''death-inducing signaling complex'' (DISC), which contains the FADD, caspase-8 and caspase-10. In some types of cells (type I), processed caspase-8 directly activates other members of the caspase family, and triggers the execution of apoptosis of the cell. In other types of cells (type II), the ''Fas''-DISC starts a feedback loop that spirals into increasing release of proapoptotic factors from mitochondria and the amplified activation of caspase-8.<ref name="fassignal">{{cite journal| vauthors=Wajant H| title=Connection Map for Fas Signaling Pathway| journal=[[Science Signaling|Science's STKE]]| url=http://stke.sciencemag.org/cgi/cm/CMP_7966| doi=10.1126/stke.3802007tr1| volume=2007| issue=380| pages=tr1| year=2007| s2cid=84909531| access-date=2004-01-01| archive-date=2009-05-03| archive-url=https://web.archive.org/web/20090503010824/http://stke.sciencemag.org/cgi/cm/CMP_7966| url-status=dead}}</ref>