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===Haemosporidia=== [[File:Immature and mature trophozoites of the Plasmodium vivax parasite PHIL 2720 lores.jpg|thumb|150px|upright=1.3|Trophozoites of the ''[[Plasmodium vivax]]'' (Haemosporidia) parasite among human red blood cells]] {{Main|Haemosporida}} The Haemosporidia have more complex lifecycles that alternate between an arthropod and a vertebrate host. The trophozoite parasitises [[erythrocyte]]s or other tissues in the vertebrate host. Microgametes and macrogametes are always found in the blood. The gametes are taken up by the insect vector during a blood meal. The microgametes migrate within the gut of the insect vector and fuse with the macrogametes. The fertilized macrogamete now becomes an [[ookinete]], which penetrates the body of the vector. The ookinete then transforms into an oocyst and divides initially by meiosis and then by mitosis (haplontic lifecycle) to give rise to the [[sporozoite]]s. The sporozoites escape from the oocyst and migrate within the body of the vector to the salivary glands where they are injected into the new vertebrate host when the insect vector feeds again.<ref>{{Cite journal |last1=Frischknecht |first1=Friedrich |last2=Matuschewski |first2=Kai |date=2017-01-20 |title=''Plasmodium'' Sporozoite Biology |journal=Cold Spring Harbor Perspectives in Medicine |language=en |volume=7 |issue=5 |pages=a025478 |doi=10.1101/cshperspect.a025478 |pmid=28108531 |pmc=5411682 |issn=2157-1422}}</ref>
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