Editing Iron (section)

===Cancer===
The role of iron in cancer defense can be described as a "double-edged sword" because of its pervasive presence in non-pathological processes.<ref>{{cite book|last1=Thévenod|first1=Frank
|editor1-last=Sigel|editor1-first=Astrid|editor2-last=Sigel|editor2-first=Helmut|editor3-last=Freisinger|editor3-first=Eva|editor4-last=Sigel|editor4-first=Roland K. O.
|title=Metallo-Drugs: Development and Action of Anticancer Agents
|date=2018
|doi= 10.1515/9783110470734-021
|pmid=29394034
|publisher=de Gruyter GmbH
|location=Berlin
|chapter= Chapter 15. Iron and Its Role in Cancer Defense: A Double-Edged Sword
|series=Metal Ions in Life Sciences 18
|volume=18
|pages= 437–67}}
</ref> People having [[chemotherapy]] may develop iron deficiency and [[anemia]], for which [[Intravenous iron infusion|intravenous iron therapy]] is used to restore iron levels.<ref name="beguin">{{cite journal|pmid=24275533|year=2014|last1=Beguin|first1=Y|title=Epidemiological and nonclinical studies investigating effects of iron in carcinogenesis--a critical review|journal=Critical Reviews in Oncology/Hematology|volume=89|issue=1|pages=1–15|last2=Aapro|first2=M|last3=Ludwig|first3=H|last4=Mizzen|first4=L|last5=Osterborg|first5=A|doi=10.1016/j.critrevonc.2013.10.008|doi-access=free}}</ref> Iron overload, which may occur from high consumption of red meat,<ref name="lpi" /> may initiate [[tumor]] growth and increase susceptibility to cancer onset,<ref name="beguin" /> particularly for [[colorectal cancer]].<ref name="lpi" />
<!--===Bioremediation===

Iron-eating bacteria live in the hulls of [[sunken ship]]s such as the ''[[Titanic]]''.<ref>{{cite book
  | last = Ward
  | first = Greg
  | title = The Rough Guide to the ''Titanic''
  | date = 2012
  | publisher = Rough Guides Ltd
  | location = London
  | page=171
  | isbn = 978-1-4053-8699-9
  }}</ref> The acidophile bacteria ''[[Acidithiobacillus|Acidithiobacillus ferrooxidans]]'', ''[[Leptospirillum ferrooxidans]]'', ''[[Sulfolobus]]'' spp., ''[[Acidianus|Acidianus brierleyi]]'' and ''[[Sulfobacillus thermosulfidooxidans]]'' can oxidize ferrous iron enzymically.<ref>{{cite journal|url=https://mic.sgmjournals.org/content/156/3/609.full|title=Metals, minerals and microbes: geomicrobiology and bioremediation|journal=Microbiology|last=Gadd |first= Geoffrey Michael |volume=156|date=March 2010|pages=609–43|doi=10.1099/mic.0.037143-0|pmid=20019082|issue=3}}</ref> A sample of the fungus ''[[Aspergillus niger]]'' was found growing from gold mining solution, and was found to contain cyano metal complexes such as gold, silver, copper iron and zinc. The fungus also plays a role in the solubilization of heavy metal sulfides.<ref>{{cite book|url={{Google books|WY3YvfNoouMC|page=PA533|keywords=|text=|plainurl=yes}}|title=Mycoremediation: Fungal Bioremediation|last=Singh |first= Harbhajan |page=509}}</ref>-->