Editing Vitamin B6 (section)

===Commercial synthesis===
The starting material is either the amino acid [[alanine]], or [[propionic acid]] converted into alanine via [[halogenation]] and [[amination]]. Then, the procedure accomplishes the conversion of the amino acid into pyridoxine through the formation of an [[oxazole]] intermediate followed by a [[Diels–Alder reaction]], with the entire process referred to as the "oxazole method".<ref name="Bachman2018"/><ref name=Anie>{{cite journal |doi=10.1002/anie.201205886 |title=One Hundred Years of Vitamins-A Success Story of the Natural Sciences |year=2012 |last1=Eggersdorfer |first1=Manfred |last2=Laudert |first2=Dietmar |last3=Létinois |first3=Ulla |last4=McClymont |first4=Tom |last5=Medlock |first5=Jonathan |last6=Netscher |first6=Thomas |last7=Bonrath |first7=Werner |journal=Angewandte Chemie International Edition |volume=51 |issue=52 |pages=12973–12974 |pmid=23208776 }}</ref> The product used in dietary supplements and [[food fortification]] is [[pyridoxine hydrochloride]], the chemically stable [[hydrochloride]] salt of pyridoxine.<ref name="Wang2021"/> Pyridoxine is converted in the liver into the metabolically active coenzyme form pyridoxal 5'-phosphate. At present, while the industry mainly utilizes the oxazole method, there is research exploring means of using less toxic and dangerous reagents in the process.<ref name="Zou2013">{{cite journal |vauthors=Zou E, Shi X, Zhang G, Li Z, Jin C, Su W |title=Improved "Oxazole" Method for the Practical and Efficient Preparation of Pyridoxine Hydrochloride (Vitamin B<sub>6</sub>) |journal=Org Process Res Dev |volume=17 |issue=12 |pages=1498–502 |doi=10.1021/op4001687 |date=November 2013 |url=https://pubs.acs.org/doi/10.1021/op4001687 |url-access=subscription |access-date=August 16, 2021 |archive-date=May 22, 2022 |archive-url=https://web.archive.org/web/20220522062107/https://pubs.acs.org/doi/10.1021/op4001687 |url-status=live }}</ref> Fermentative bacterial biosynthesis methods are also being explored, but are not yet scaled up for commercial production.<ref name="Wang2021">{{cite journal |vauthors=Wang Y, Liu L, Jin Z, Zhang D |title=Microbial Cell Factories for Green Production of Vitamins |journal=Front Bioeng Biotechnol |volume=9 |issue= |pages=661562 |date=2021 |pmid=34222212 |pmc=8247775 |doi=10.3389/fbioe.2021.661562 |url=|doi-access=free }}</ref>