Editing Skin (section)

===Dermis===
{{main|Dermis}}

The '''dermis''' is the layer of skin beneath the [[epidermis (skin)|epidermis]] that consists of [[connective tissue]] and cushions the body from [[stress (biology)|stress]] and strain. The [[dermis]] provides tensile [[strength of materials|strength]] and [[elasticity (physics)|elasticity]] to the skin through an [[extracellular matrix]] composed of [[collagen fibrils]], [[microfibrils]], and [[elastic fibers]], embedded in [[hyaluronan]] and [[proteoglycan]]s.<ref name="Pmid" /> Skin proteoglycans  are varied and have very specific locations.<ref>{{cite journal |last1=Smith |first1=Margaret Mary |last2=Melrose |first2=James |title=Proteoglycans in Normal and Healing Skin |journal=Advances in Wound Care |date=March 2015 |volume=4 |issue=3 |pages=152–173 |doi=10.1089/wound.2013.0464 |pmid=25785238 |pmc=4352701 }}</ref> For example, [[hyaluronan]], [[versican]] and [[decorin]] are present throughout the dermis and [[epidermis]] [[extracellular matrix]], whereas [[biglycan]] and [[perlecan]] are only found in the epidermis.

It harbors many [[mechanoreceptor]]s (nerve endings) that provide the sense of [[touch]] and heat through [[nociceptor]]s and [[thermoreceptor]]s. It also contains the [[hair follicle]]s, [[sweat gland]]s, [[sebaceous gland]]s, [[apocrine glands]], [[lymphatic vessel]]s and [[blood vessel]]s. The [[blood vessel]]s in the [[dermis]] provide nourishment and waste removal from its own [[cell (biology)|cells]] as well as for the [[epidermis (skin)|epidermis]].

Dermis and subcutaneous tissues are thought to contain germinative cells involved in formation of horns, osteoderm, and other extra-skeletal apparatus in mammals.<ref name=":2" />

The [[dermis]] is tightly connected to the [[epidermis (skin)|epidermis]] through a [[basement membrane]] and is structurally divided into two areas: a superficial area adjacent to the epidermis, called the ''papillary region'', and a deep thicker area known as the ''reticular region''.

====Papillary region====
The papillary region is composed of loose [[areolar connective tissue]]. This is named for its fingerlike projections called ''papillae'' that extend toward the [[epidermis (skin)|epidermis]]. The papillae provide the [[dermis]] with a "bumpy" surface that interdigitates with the epidermis, strengthening the connection between the two layers of skin.

====Reticular region====
The reticular region lies deep in the papillary region and is usually much thicker. It is composed of dense irregular [[connective tissue]] and receives its name from the dense concentration of [[collagen]]ous, [[Elastic fibers|elastic]], and [[Reticular fiber|reticular]] fibers that weave throughout it. These [[protein]] fibers give the [[dermis]] its properties of [[strength of materials|strength]], [[extensibility]], and [[elasticity (physics)|elasticity]].
Also located within the reticular region are the [[roots of the hair]], [[sweat gland]]s, [[sebaceous gland]]s, [[Cutaneous receptor|receptors]], [[nail (anatomy)|nails]], and [[blood vessel]]s.