Editing Signal transduction (section)

===Temperature===
{{Main|Thermoception}}
The sensing of temperature in cells is known as thermoception and is primarily mediated by [[transient receptor potential channel]]s.<ref name="Sengupta">{{Cite journal |vauthors=Sengupta P, Garrity P |date=April 2013 |title=Sensing temperature |journal=Current Biology |volume=23 |issue=8 |pages=R304-7 |doi=10.1016/j.cub.2013.03.009 |pmc=3685181 |pmid=23618661}}</ref> Additionally, animal cells contain a conserved mechanism to prevent high temperatures from causing cellular damage, the [[heat-shock response]]. Such response is triggered when high temperatures cause the dissociation of inactive [[HSF1]] from complexes with [[heat shock proteins]] [[Hsp40]]/[[Hsp70]] and [[Hsp90]]. With help from the [[ncRNA]] ''hsr1'', HSF1 then trimerizes, becoming active and upregulating the expression of its target genes.<ref>{{Cite journal |vauthors=Shamovsky I, Ivannikov M, Kandel ES, Gershon D, Nudler E |date=March 2006 |title=RNA-mediated response to heat shock in mammalian cells |journal=Nature |volume=440 |issue=7083 |pages=556–60 |bibcode=2006Natur.440..556S |doi=10.1038/nature04518 |pmid=16554823 |s2cid=4311262}}</ref> Many other thermosensory mechanisms exist in both [[prokaryotes]] and [[eukaryotes]].<ref name="Sengupta" />