Editing Salvinorin A (section)

=== Effect on intestinal motility ===

Salvinorin A is capable of inhibiting excess [[intestinal motility]] (e.g. diarrhea), through its potent κ-opioid-activating effects. The mechanism of action for salvinorin&nbsp;A on [[ileum|ileal]] tissue has been described as 'prejunctional', as it was able to modify electrically induced contractions, but not those of [[exogenous]] [[acetylcholine]].<ref name=Capasso2006/> A pharmacologically important aspect of the contraction-reducing properties of ingested salvinorin&nbsp;A on gut tissue is that it is only pharmacologically active on inflamed and not normal tissue, thus reducing possible side-effects.<ref name=Capasso2007/>