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=== Evidence quality === A 2008 [[systematic review]] of nine [[randomized clinical trial]]s found several shortcomings in the literature on reiki.<ref name="Lee_Pittler_Ernst_2008" /> Depending on the tools used to measure [[Major depressive disorder|depression]] and [[anxiety]], the results varied and were not reliable or valid. Furthermore, the scientific community has been unable to replicate the findings of studies that support reiki. The review also found issues in reporting methodology in some of the literature, in that often there were parts omitted completely or not clearly described.<ref name="Lee_Pittler_Ernst_2008" /> Frequently in these studies, sample sizes were not calculated and adequate allocation and double-blind procedures were not followed. The review also reported that such studies exaggerated the effectiveness of treatment and there was no control for differences in experience of reiki practitioners or even the same practitioner at times produced different outcomes. None of the studies in the review provided a rationale for the treatment duration and no study reported adverse effects.<ref name="Lee_Pittler_Ernst_2008" />
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