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== Enforcement of labeling and future ramifications == The Pure Food and Drug Act was initially concerned with ensuring products were labeled correctly. Later efforts were made to outlaw certain products that were not safe, followed by efforts to outlaw products which were safe but not effective. For example, there was an attempt to outlaw [[Coca-Cola]] in 1909 because of its excessive caffeine content; caffeine had replaced cocaine as the active ingredient in Coca-Cola in 1903.<ref>{{cite magazine |url=https://www.theatlantic.com/health/archive/2013/01/why-we-took-cocaine-out-of-soda/272694/ |title=Why We Took Cocaine Out of Soda |author=Hamblin M.D., James |date=January 31, 2013 |series=The Atlantic's Health Editorial |magazine=The Atlantic Monthly |access-date=April 10, 2013}}</ref> In the case ''[[United States v. Forty Barrels and Twenty Kegs of Coca-Cola]]'', the judge found that Coca-Cola had a right to use caffeine as it saw fit, although Coca-Cola eventually lost when the government appealed to the Supreme Court.<ref>"[http://www.apa.org/monitor/2009/02/coca-cola.aspx Pop psychology: The man who saved Coca-Cola]", by Ludy T. Benjamin, ''Monitor on Psychology,'' February 2009, Vol 40, No. 2, p. 18</ref> It reached a settlement with the [[United States government]] to reduce the caffeine amount. In addition to caffeine, the Pure Food and Drug Act required that drugs such as [[alcohol (drug)|alcohol]], [[cocaine]], [[heroin]], [[morphine]], and [[cannabis (drug)|cannabis]], be accurately labeled with contents and dosage. Previously many drugs had been sold as [[patent medicines]] with secret ingredients or misleading labels. Cocaine, heroin, cannabis, and other such drugs continued to be legally available without prescription as long as they were labeled. It is estimated that sale of patent medicines containing [[opiates]] decreased by 33% after labeling was mandated.<ref>{{cite book | last =Musto | first =David F. | year =1999|edition=3rd | title =The American Disease: Origins of Narcotic Control | publisher =Oxford University Press | isbn = 0-19-512509-6 | url = https://books.google.com/books?id=7VrQy2d8PxYC }}</ref> The Pure Food and Drug Act of 1906 is cited by [[drug policy reform]] advocates such as [[Jim Gray (jurist)|Jim Gray]] as a successful model for [[drug liberalization|re-legalization]] of currently [[prohibition (drugs)|prohibited drugs]] by requiring accurate labels, monitoring of purity and dose, and [[consumer education]].<ref>{{cite book |title=Why Our Drug Laws Have Failed and What We Can Do About It: A Judicial Indictment of the War on Drugs |url=https://archive.org/details/whyourdruglawsha00gray/page/288 |url-access=registration |author=Gray, James P. |date=May 2, 2001 |publisher=Temple University Press |pages=[https://archive.org/details/whyourdruglawsha00gray/page/288 288] |isbn=978-1566398602 }}</ref>
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