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=== Nutritional === Gastric acid is important for breakdown of food and release of [[Micronutrient|micronutrients]], and some studies have shown possibilities for interference with absorption of [[iron]], [[calcium]], [[magnesium]], and [[Cyanocobalamin|vitamin B<sub>12</sub>]].<nowiki><ref name="pmid20882439"></nowiki>{{cite journal |vauthors=Ito T, Jensen RT |date=December 2010 |title=Association of long-term proton pump inhibitor therapy with bone fractures and effects on absorption of calcium, vitamin B12, iron, and magnesium |journal=Current Gastroenterology Reports |volume=12 |issue=6 |pages=448β57 |doi=10.1007/s11894-010-0141-0 |pmc=2974811 |pmid=20882439}}</ref> These findings suggest that long-term PPI use may negatively affect bone health in men.
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