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=== HIV/AIDS === The [[Centers for Disease Control and Prevention]] (CDC) included certain types of non-Hodgkin lymphoma as AIDS-defining cancers in 1987.<ref>{{cite journal | title = Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. Council of State and Territorial Epidemiologists; AIDS Program, Center for Infectious Diseases | journal = MMWR Supplements | volume = 36 | issue = 1 | pages = 1Sβ15S | date = August 1987 | pmid = 3039334 | url = https://www.cdc.gov/mmwr/pdf/other/mmsu3601.pdf | url-status = live | archive-url = https://web.archive.org/web/20170609012431/https://www.cdc.gov/mmwr/pdf/other/mmsu3601.pdf | df = dmy | archive-date = 9 June 2017 | author1 = Centers for Disease Control (CDC) }}</ref> Immune suppression rather than HIV itself is implicated in the pathogenesis of this malignancy, with a clear correlation between the degree of immune suppression and the risk of developing NHL. Additionally, other retroviruses, such as [[HTLV]], may be spread by the same mechanisms that spread [[HIV]], leading to an increased rate of co-infection.<ref>{{cite journal| vauthors = Lee B, Bower M, Newsom-Davis T, Nelson M |title=HIV-related lymphoma|journal=HIV Therapy|volume=4|issue=6|year=2010|pages=649β659|issn=1758-4310|doi=10.2217/hiv.10.54}}</ref> The natural history of HIV infection has greatly changed over time. As a consequence, rates of non-Hodgkin lymphoma (NHL) in people infected with HIV has significantly declined in recent years.<ref name="PinzoneFiorica2012">{{cite journal | vauthors = Pinzone MR, Fiorica F, Di Rosa M, Malaguarnera G, Malaguarnera L, Cacopardo B, ZanghΓ¬ G, Nunnari G | title = Non-AIDS-defining cancers among HIV-infected people | journal = European Review for Medical and Pharmacological Sciences | volume = 16 | issue = 10 | pages = 1377β88 | date = October 2012 | pmid = 23104654 }}</ref>
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