Editing Nociception (section)

=== Mechanical ===
{{See also|Neuropathic pain}}
Proprioception is determined by using standard mechanoreceptors (especially [[ruffini corpuscle]]s (stretch) and [[transient receptor potential channel]]s (TRP channels). Proprioception is completely covered within the [[somatosensory system]], as the brain processes them together.

Thermoception refers to stimuli of moderate temperatures {{convert|24|&ndash;|28|C|F}}, as anything beyond that range is considered pain and moderated by nociceptors. TRP and potassium channels [TRPM (1-8), TRPV (1-6), TRAAK, and TREK] each respond to different temperatures (among other stimuli), which create action potentials in nerves that join the mechano (touch) system in the posterolateral tract. Thermoception, like proprioception, is then covered by the somatosensory system.<ref>{{cite book |last1=McCann |first1=Stephanie |title=Kaplan Medical Anatomy Flashcards: Clearly Labeled, Full-Color Cards |date=2017 |publisher=KAPLAN |isbn=978-1-5062-2353-7 }}{{page needed|date=May 2020}}</ref><ref>Albertine, Kurt. Barron's Anatomy Flash Cards{{page needed|date=May 2020}}</ref><ref>{{cite journal |last1=Hofmann |first1=Thomas |last2=Schaefer |first2=Michael |last3=Schultz |first3=Günter |last4=Gudermann |first4=Thomas |title=Subunit composition of mammalian transient receptor potential channels in living cells |journal=Proceedings of the National Academy of Sciences |date=28 May 2002 |volume=99 |issue=11 |pages=7461–7466 |doi=10.1073/pnas.102596199 |pmid=12032305 |pmc=124253 |bibcode=2002PNAS...99.7461H |doi-access=free }}</ref><ref>{{cite journal |last1=Noël |first1=Jacques |last2=Zimmermann |first2=Katharina |last3=Busserolles |first3=Jérome |last4=Deval |first4=Emanuel |last5=Alloui |first5=Abdelkrim |last6=Diochot |first6=Sylvie |last7=Guy |first7=Nicolas |last8=Borsotto |first8=Marc |last9=Reeh |first9=Peter |last10=Eschalier |first10=Alain |last11=Lazdunski |first11=Michel |title=The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception |journal=The EMBO Journal |date=12 March 2009 |volume=28 |issue=9 |pages=1308–1318 |doi=10.1038/emboj.2009.57 |pmid=19279663 |pmc=2683043 }}</ref><ref>{{cite journal |last1=Scholz |first1=Joachim |last2=Woolf |first2=Clifford J. |title=Can we conquer pain? |journal=Nature Neuroscience |date=November 2002 |volume=5 |issue=11 |pages=1062–1067 |doi=10.1038/nn942 |pmid=12403987 |s2cid=15781811 }}</ref>

TRP channels that detect noxious stimuli (mechanical, thermal, and chemical pain) relay that information to nociceptors that generate an action potential. Mechanical TRP channels react to depression of their cells (like touch), thermal TRPs change shape in different temperatures, and chemical TRPs act like [[taste bud]]s, signalling if their receptors bond to certain elements/chemicals.