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===Schizophrenia=== It has been shown that a certain protein [[synaptophysin]]<ref>{{cite journal |last1=Osimo |first1=Emanuele Felice |last2=Beck |first2=Katherine |last3=Reis Marques |first3=Tiago |last4=Howes |first4=Oliver D |title=Synaptic loss in schizophrenia: a meta-analysis and systematic review of synaptic protein and mRNA measures |journal=Molecular Psychiatry |date=2019 |volume=24 |issue=4 |pages=549β561 |doi=10.1038/s41380-018-0041-5 |pmid=29511299 |pmc=6004314 }}</ref> is lost in people with [[schizophrenia]] that causes dendrites and spines to deteriorate in the [[dorsolateral prefrontal cortex]], a part of the neocortex, which plays a key role in information processing, attention, memory, orderly thinking and planning which are all functions that deteriorate in people with schizophrenia. The deterioration of the neuropil in this cortex has been proposed as a contributor to schizophrenia pathophysiology.{{cn|date=February 2022}}
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