Editing Mitochondrial disease (section)

==Mechanisms==

The effective overall energy unit for the available body energy is referred to as the daily [[glycogen]] generation capacity,<ref name=Chemiosomosis >{{cite web|last=Mitchell|first=Peter|title=David Keilin's respiratory chain concept and its chemiosmotic consequences|url=https://www.nobelprize.org/nobel_prizes/chemistry/laureates/1978/mitchell-lecture.pdf|publisher=Nobel institute}}</ref><ref name=Dichloroacetate >{{cite journal|last=Michelakis|first=Evangelos|title=A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth|journal=University of Alberta|publisher=University of Alberta, 2007|doi=10.1016/j.ccr.2006.10.020|volume=11|issue=1|pages=37–51|pmid=17222789|date=January 2007|doi-access=free}}</ref><ref name="Lorini & Ciman" >{{cite journal|last=Lorini & Ciman|first=M, & M|title=Hypoglycaemic action of Diisopropylammonium salts in experimental diabetes|journal=Institute of Biochemistry, University of Padua, September 1962|publisher=Biochemical Pharmacology|doi=10.1016/0006-2952(62)90177-6|volume=11|issue=9|pages=823–827|year=1962|pmid=14466716}}</ref> and is used to compare the mitochondrial output of affected or chronically glycogen-depleted individuals to healthy individuals.<ref name=Dichloroacetate/>

The glycogen generation capacity is entirely dependent on, and determined by, the operating levels of the [[mitochondria]] in all of the [[Cell (biology)|cells]] of the [[human body]];<ref name="Dichloroacetate pharmacology" >{{cite journal |vauthors = Stacpoole PW, Henderson GN, Yan Z, James MO |title = Clinical pharmacology and toxicology of dichloroacetate |journal = Environ. Health Perspect. |volume = 106 |pages = 989–94 |year = 1998 |issue = Suppl 4 |pmid = 9703483 |pmc = 1533324 |doi=10.1289/ehp.98106s4989|bibcode = 1998EnvHP.106S.989S }}</ref> however, the relation between the [[energy]] generated by the mitochondria and the glycogen capacity is very loose and is mediated by many [[biochemical pathways]].<ref name=Chemiosomosis /> The energy output of full healthy mitochondrial function can be predicted exactly by a complicated theoretical argument, but this argument is not straightforward, as most energy is consumed by the brain and is not easily measurable.