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Medical uses of silver
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===Endotracheal tubes=== A 2015 systematic review concluded that the limited evidence available indicates that using silver-coated [[endotracheal tube|endotracheal breathing tubes]] reduces the risk of contracting [[ventilator-associated pneumonia]] (VAP), especially during the initial days of utilisation.<ref>{{cite journal | vauthors = Tokmaji G, Vermeulen H, MΓΌller MC, Kwakman PH, Schultz MJ, Zaat SA | title = Silver-coated endotracheal tubes for prevention of ventilator-associated pneumonia in critically ill patients | journal = The Cochrane Database of Systematic Reviews | issue = 8 | pages = CD009201 | date = August 2015 | volume = 2015 | pmid = 26266942 | doi = 10.1002/14651858.CD009201 | pmc = 6517140 | veditors = Tokmaji G }}</ref> A 2014 study concluded that using silver-coated endotracheal tubes will help to prevent VAP and that this may save on hospital costs.<ref>{{cite journal | vauthors = Shorr AF, Zilberberg MD, Kollef M | title = Cost-effectiveness analysis of a silver-coated endotracheal tube to reduce the incidence of ventilator-associated pneumonia | journal = Infection Control and Hospital Epidemiology | volume = 30 | issue = 8 | pages = 759β763 | date = August 2009 | pmid = 19538095 | doi = 10.1086/599005 | s2cid = 14809364 | url = https://digitalcommons.wustl.edu/open_access_pubs/820 }}</ref> A 2012 systematic review of randomized controlled trials concluded that the limited evidence available indicates that using silver-coated endotracheal tubes will reduce the incidence of ventilator-associated pneumonia, microbiologic burden, and device-related adverse events among adult patients.<ref>{{cite journal | vauthors = Li X, Yuan Q, Wang L, Du L, Deng L | title = Silver-coated endotracheal tube versus non-coated endotracheal tube for preventing ventilator-associated pneumonia among adults: a systematic review of randomized controlled trials | journal = Journal of Evidence-Based Medicine | volume = 5 | issue = 1 | pages = 25β30 | date = February 2012 | pmid = 23528117 | doi = 10.1111/j.1756-5391.2012.01165.x | s2cid = 23720955 }}</ref> Another 2012 review agreed that the use of silver-coated endotracheal tubes reduces the prevalence of VAP in intubated patients, but cautioned that this on its own is not sufficient to prevent infection. They also suggested that more research is needed to establish the cost-effectiveness of the treatment.<ref name=pmid23035371>{{cite journal | vauthors = Kane T, Claman F | title = Silver tube coatings in pneumonia prevention | journal = Nursing Times | volume = 108 | issue = 36 | pages = 21β23 | year = 2012 | pmid = 23035371 }}</ref> Another 2012 study agreed that there is evidence that endotracheal tubes coated with silver may reduce the incidence of [[ventilator associated pneumonia]] (VAP) and delay its onset, but concluded that no benefit was seen in the duration of intubation, the duration of stay in intensive care or the mortality rate. They also raised concerns surrounding the [[unblinded trial|unblinded]] nature of some of the studies then available.<ref name="pmid22744316"/> The U.S. Food and Drug Administration in 2007 cleared an endotracheal tube with a fine coat of silver to reduce the risk of ventilator-associated [[pneumonia]].<ref name=FDASilver2007>{{cite web|url= https://www.fda.gov/bbs/topics/NEWS/2007/NEW01741.html| title= FDA Clears Silver-Coated Breathing Tube For Marketing| publisher = [[Food and Drug Administration]]|date= 2007-11-08|archive-url=https://web.archive.org/web/20071114040503/https://www.fda.gov/bbs/topics/NEWS/2007/NEW01741.html|archive-date=November 14, 2007}}</ref>
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