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=== Human & other organisms === Isoprene is the most abundant hydrocarbon measurable in the breath of humans.<ref name="Gelmont">{{cite journal | vauthors = Gelmont D, Stein RA, Mead JF | title = Isoprene-the main hydrocarbon in human breath | journal = Biochemical and Biophysical Research Communications | volume = 99 | issue = 4 | pages = 1456–60 | date = April 1981 | pmid = 7259787 | doi = 10.1016/0006-291X(81)90782-8 }}</ref><ref name="King">{{cite journal | vauthors = King J, Koc H, Unterkofler K, Mochalski P, Kupferthaler A, Teschl G, Teschl S, Hinterhuber H, Amann A | display-authors = 6 | title = Physiological modeling of isoprene dynamics in exhaled breath | journal = Journal of Theoretical Biology | volume = 267 | issue = 4 | pages = 626–37 | date = December 2010 | pmid = 20869370 | doi = 10.1016/j.jtbi.2010.09.028 | arxiv = 1010.2145 | bibcode = 2010JThBi.267..626K | s2cid = 10267120 | author7-link = Susanne Teschl }}</ref><ref>{{cite journal | vauthors = Williams J, Stönner C, Wicker J, Krauter N, Derstroff B, Bourtsoukidis E, Klüpfel T, Kramer S | display-authors = 6 | title = Cinema audiences reproducibly vary the chemical composition of air during films, by broadcasting scene specific emissions on breath | journal = Scientific Reports | volume = 6 | pages = 25464 | date = May 2016 | pmid = 27160439 | doi = 10.1038/srep25464 | pmc = 4862009 | bibcode = 2016NatSR...625464W }}</ref> The estimated production rate of isoprene in the human body is 0.15 [[mole (unit)|μmol]]/(kg·h), equivalent to approximately 17 mg/day for a person weighing 70 kg. Human breath isoprene originates from lipolytic cholesterol metabolism within the skeletal muscular peroxisomes and ''IDI2'' gene acts as the production determinant.<ref>{{Cite journal |last=Sukul |first=Pritam |last2=Richter |first2=Anna |last3=Junghanss |first3=Christian |last4=Schubert |first4=Jochen K. |last5=Miekisch |first5=Wolfram |date=2023-09-30 |title=Origin of breath isoprene in humans is revealed via multi-omic investigations |url=https://www.nature.com/articles/s42003-023-05384-y |journal=Communications Biology |language=en |volume=6 |issue=1 |pages=1–12 |doi=10.1038/s42003-023-05384-y |issn=2399-3642|pmc=10542801 }}</ref> Due to the absence of ''IDI2'' gene, animals such as pigs and bottle-nose dolphins do not exhale isoprene. Isoprene is common in low concentrations in many foods. Many species of soil and marine bacteria, such as [[Actinomycetota]], are capable of degrading isoprene and using it as a fuel source. [[File:PolyIsopreneCorrected.svg|thumb|350px|left|Chemical structure of ''cis''-polyisoprene, the main constituent of natural rubber]]
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