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===Species specificity=== Another advantage of ''in vitro'' methods is that human cells can be studied without "extrapolation" from an experimental animal's cellular response.<ref> {{Cite web |date = 20 November 2016 |archive-date=March 13, 2020 | title = Existing Non-animal Alternatives | publisher = AltTox.org |url = http://alttox.org/mapp/table-of-validated-and-accepted-alternative-methods/ |archive-url = https://web.archive.org/web/20200313140353/http://alttox.org/mapp/table-of-validated-and-accepted-alternative-methods/ |url-status = dead }}</ref><ref>{{Cite journal |last1=Pound |first1=Pandora |last2=Ritskes-Hoitinga |first2=Merel |date=2018-11-07 |title=Is it possible to overcome issues of external validity in preclinical animal research? Why most animal models are bound to fail |journal=Journal of Translational Medicine |volume=16 |issue=1 |pages=304 |doi=10.1186/s12967-018-1678-1 |issn=1479-5876 |pmc=6223056 |pmid=30404629 |doi-access=free }}</ref><ref>{{Cite journal |last=Zeiss |first=Caroline J. |date=December 2021 |title=Comparative Milestones in Rodent and Human Postnatal Central Nervous System Development |url=http://journals.sagepub.com/doi/10.1177/01926233211046933 |journal=Toxicologic Pathology |language=en |volume=49 |issue=8 |pages=1368β1373 |doi=10.1177/01926233211046933 |pmid=34569375 |s2cid=237944066 |issn=0192-6233}}</ref>
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