Editing Euchromatin (section)

=== Epigenetics ===
[[Epigenetics]] involves changes in the [[phenotype]] that can be inherited without changing the DNA sequence. This can occur through many types of environmental interactions.<ref>{{cite journal | vauthors = Arney KL, Fisher AG | title = Epigenetic aspects of differentiation | journal = Journal of Cell Science | volume = 117 | issue = Pt 19 | pages = 4355–4363 | date = September 2004 | pmid = 15331660 | doi = 10.1242/jcs.01390 | s2cid = 24376600 }}</ref> Regarding euchromatin, [[Euchromatin#Regulation|post-translational modifications of the histones]] can alter the structure of chromatin, resulting in altered gene expression without changing the DNA.<ref>{{cite journal | vauthors = Singh NP, Madabhushi SR, Srivastava S, Senthilkumar R, Neeraja C, Khosla S, Mishra RK | title = Epigenetic profile of the euchromatic region of human Y chromosome | journal = Nucleic Acids Research | volume = 39 | issue = 9 | pages = 3594–3606 | date = May 2011 | pmid = 21252296 | pmc = 3089472 | doi = 10.1093/nar/gkq1342 }}</ref> Additionally, a loss of heterochromatin and increase in euchromatin has been shown to correlate with an accelerated [[Ageing|aging process]], especially in [[Progeroid syndromes|diseases known to resemble premature aging]].<ref>{{cite journal | vauthors = Wang J, Jia ST, Jia S | title = New Insights into the Regulation of Heterochromatin | journal = Trends in Genetics | volume = 32 | issue = 5 | pages = 284–294 | date = May 2016 | pmid = 27005444 | doi = 10.1016/j.tig.2016.02.005 | pmc = 4842111 }}</ref> Research has shown epigenetic markers on histones for a number of additional diseases.<ref>{{Cite journal | title = Epigenetic Influences and Disease | vauthors = Simmons D | date = 2008 | journal = Nature Education | volume = 1 | issue = 1 | page = 6 |url= http://www.nature.com/scitable/topicpage/epigenetic-influences-and-disease-895|access-date=2021-12-02 }}</ref><ref>{{cite journal | vauthors = Alaskhar Alhamwe B, Khalaila R, Wolf J, von Bülow V, Harb H, Alhamdan F, Hii CS, Prescott SL, Ferrante A, Renz H, Garn H, Potaczek DP | display-authors = 6 | title = Histone modifications and their role in epigenetics of atopy and allergic diseases | journal = Allergy, Asthma, and Clinical Immunology | volume = 14 | issue = 1 | page = 39 | date = 2018-05-23 | pmid = 29796022 | pmc = 5966915 | doi = 10.1186/s13223-018-0259-4 | doi-access = free }}</ref>