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==Side effects== Ephedrine is a potentially dangerous natural compound; {{as of|2004|lc=yes}} the US [[Food and Drug Administration]] (FDA) had received over 18,000 reports of adverse effects in people using it.<ref name="Palamar2011" /> [[Adverse drug reaction]]s (ADRs) are more common with systemic administration (e.g. injection or oral administration) compared to topical administration (e.g. nasal instillations). ADRs associated with ephedrine therapy include <ref name=JFC>Joint Formulary Committee. [[British National Formulary]], 47th edition. London: British Medical Association and Royal Pharmaceutical Society of Great Britain; 2004. {{ISBN|0-85369-587-3}}</ref> * Cardiovascular: [[tachycardia]], cardiac [[Heart arrhythmia|arrhythmia]]s, [[angina pectoris]], [[vasoconstriction]] with [[hypertension]] * [[Dermatology|Dermatological]]: flushing, sweating, [[acne vulgaris]] * [[Gastrointestinal tract|Gastrointestinal]]: nausea * [[Genitourinary system|Genitourinary]]: decreased urination due to vasoconstriction of renal arteries, difficulty urinating is not uncommon, as alpha-agonists such as ephedrine constrict the internal urethral sphincter, mimicking the effects of sympathetic nervous system stimulation * [[Nervous system]]: restlessness, [[confusion]], [[insomnia]], mild euphoria, [[mania]]/[[hallucinations]] (rare except in previously existing psychiatric conditions), [[delusions]], [[formication]] (may be possible, but lacks documented evidence) [[paranoia]], [[hostility]], [[panic]], [[Psychomotor agitation|agitation]] * [[Respiratory system|Respiratory]]: [[dyspnea]], pulmonary edema * Miscellaneous: dizziness, headache, tremor, [[hyperglycemia|hyperglycemic]] reactions, dry mouth
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