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==Regulation== [[Norepinephrine|Noradrenaline]] has been shown to increase endorphins production within inflammatory tissues, resulting in an [[Analgesic|analgesic effect]];<ref>{{cite journal | vauthors = Binder W, Mousa SA, Sitte N, Kaiser M, Stein C, Schäfer M | title = Sympathetic activation triggers endogenous opioid release and analgesia within peripheral inflamed tissue | journal = The European Journal of Neuroscience | volume = 20 | issue = 1 | pages = 92–100 | date = July 2004 | pmid = 15245482 | doi = 10.1111/j.1460-9568.2004.03459.x }}</ref> the stimulation of [[Sympathetic nervous system|sympathetic nerves]] by electro-acupuncture is believed to be the cause of its analgesic effects.{{fact|date=December 2024}}
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