Editing DNA sequencer (section)

===Life Technologies===
[[Life Technologies (Thermo Fisher Scientific)|Life Technologies]] (now [[Thermo Fisher Scientific]]) produces DNA sequencers under the [[Applied Biosystems]] and [[Ion Torrent]] brands. Applied Biosystems makes the SOLiD next-generation sequencing platform,<ref>{{Cite web|url=https://www.thermofisher.com/us/en/home/brands/applied-biosystems.html?cid=fl-appliedbiosystems|title=Applied Biosystems - US|website=www.thermofisher.com}}</ref> and Sanger-based DNA sequencers such as the 3500 Genetic Analyzer.<ref>{{Cite web|url=https://www.thermofisher.com/us/en/home/life-science/sequencing/sanger-sequencing.html|title=Sanger Sequencing and Fragment Analysis by CE - US|website=www.thermofisher.com}}</ref> Under the Ion Torrent brand, Applied Biosystems produces four next-generation sequencers: the Ion PGM System, Ion Proton System, Ion S5 and Ion S5xl systems.<ref>{{Cite web |title=Ion Torrent |url=http://www.thermofisher.com/iontorrent}}</ref> The company is also believed to be developing their new capillary DNA sequencer called SeqStudio that will be released early 2018.<ref>{{Cite web | url=https://www.thermofisher.com/us/en/home/products-and-services/promotions/life-science/seqstudio-genetic-analyzer.html | title=Applied Biosystems SeqStudio Genetic Analyzer - US}}</ref>

SOLiD systems was acquired by [[Applied Biosystems]] in 2006. SOLiD applies sequencing by ligation and [[2 base encoding|dual base encoding]]. The first SOLiD system was launched in 2007, generating reading lengths of 35bp and 3G data per run. After five upgrades, the 5500xl sequencing system was released in 2010, considerably increasing read length to 85bp, improving accuracy up to 99.99% and producing 30G per 7-day run.<ref name="Comparison Next-Gen Seq" />

The limited read length of the SOLiD has remained a significant shortcoming<ref>{{Cite web|url=https://www.thermofisher.com/us/en/home/brands/applied-biosystems.html|title=Applied Biosystems - US|website=www.thermofisher.com}}</ref> and has to some extent limited its use to experiments where read length is less vital such as resequencing and transcriptome analysis and more recently ChIP-Seq and methylation experiments.<ref name="Comparison Next-Gen Seq" /> The DNA sample preparation time for SOLiD systems has become much quicker with the automation of sequencing library preparations such as the Tecan system.<ref name="Comparison Next-Gen Seq" />

The colour space data produced by the SOLiD platform can be decoded into DNA bases for further analysis, however software that considers the original colour space information can give more accurate results. Life Technologies has released BioScope,<ref>{{Cite web|url=https://www.thermofisher.com/us/en/home/life-science/sequencing.html|title=Sequencing - US|website=www.thermofisher.com}}</ref> a data analysis package for resequencing, ChiP-Seq and transcriptome analysis. It uses the MaxMapper algorithm to map the colour space reads.