Editing Cytomegalovirus (section)

== {{anchor|Lifecycle}}Life cycle ==
Viral replication is nuclear and [[Lysogenic cycle|lysogenic.]] Entry into the host cell is achieved by attachment of the viral [[glycoproteins]] to host receptors, which mediates [[endocytosis]]. [[DNA replication|Replication]] follows the dsDNA bidirectional replication model. [[Transcription (genetics)#Elongation|DNA templated transcription]], with some [[alternative splicing]] mechanism is the method of transcription. [[Translation (biology)|Translation]] takes place by [[leaky scanning]]. The virus exits the host cell by [http://viralzone.expasy.org/all_by_species/1952.html nuclear egress], and [[Viral shedding#Via budding|budding.]] Humans and monkeys serve as the natural hosts. Transmission routes are dependent on coming into contact with bodily fluids (such as saliva, urine, and genital secretions) from an infected individual.<ref name=ViralZone /><ref>{{cite journal | vauthors = Cannon MJ, Hyde TB, Schmid DS | title = Review of cytomegalovirus shedding in bodily fluids and relevance to congenital cytomegalovirus infection | journal = Reviews in Medical Virology | volume = 21 | issue = 4 | pages = 240–255 | date = July 2011 | pmid = 21674676 | pmc = 4494736 | doi = 10.1002/rmv.695 }}</ref>

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! Genus !! Host details !! Tissue tropism !! Entry details !! Release details !! Replication site !! Assembly site !! Transmission
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|''Cytomegalovirus''||humans; monkeys||Epithelial mucosa||Glycoproteins||Budding||Nucleus||Nucleus||Urine; saliva; congenital
|}

All [[human herpesviruses|herpesviruses]] share a characteristic ability to remain [[Virus latency|latent]] within the body over long periods. Although they may be found throughout the body, CMV infections are frequently associated with the [[salivary gland]]s in humans and other [[mammal]]s.<ref name="isbn0-521-82714-0"/>