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===Oxidative phosphorylation=== {{Main|Oxidative phosphorylation|Electron transport chain|Electrochemical gradient|ATP synthase}} [[File:Oxidative phosphorylation.svg|thumb|Diagram of oxidative phosphorylation]] In eukaryotes, oxidative phosphorylation occurs in the mitochondrial [[crista]]e. It comprises the electron transport chain that establishes a [[proton gradient]] (chemiosmotic potential) across the boundary of the inner membrane by oxidizing the NADH produced from the Krebs cycle. ATP is synthesized by the ATP synthase enzyme when the chemiosmotic gradient is used to drive the phosphorylation of ADP. The electrons are finally transferred to [[exogenous]] oxygen and, with the addition of two protons, water is formed.<ref>{{Citation |last=Deshpande |first=Ojas A. |title=Biochemistry, Oxidative Phosphorylation |date=2025 |work=StatPearls |url=https://www.ncbi.nlm.nih.gov/books/NBK553192/ |access-date=2025-02-01 |place=Treasure Island (FL) |publisher=StatPearls Publishing |pmid=31985985 |last2=Mohiuddin |first2=Shamim S.}}</ref>
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