Editing Benign prostatic hyperplasia (section)

=== Degeneration ===
Benign prostatic hyperplasia is an age-related disease. Misrepair-accumulation aging theory<ref>{{cite journal | vauthors = Wang J, Michelitsch T, Wunderlin A, Mahadeva R | title = Aging as a consequence of misrepair--A novel theory of aging. | journal = Nature Precedings | date = March 2009 | doi = 10.1038/npre.2009.2988.1 | doi-access = free | arxiv = 0904.0575 }}</ref> suggests that the development of benign prostatic hyperplasia is a consequence of [[fibrosis]] and weakening of the muscular tissue in the prostate.<ref>{{cite arXiv |title = Tissue fibrosis: a principal evidence for the central role of Misrepairs in aging | vauthors = Wang-Michelitsch J, Michelitsch T |year = 2015 |class = cs.DM |eprint = 1503.01376 }}</ref> The muscular tissue is important in the functionality of the prostate, and provides the force for excreting the fluid produced by prostatic glands. However, repeated contractions and dilations of myofibers will unavoidably cause injuries and broken myofibers. Myofibers have a low potential for regeneration; therefore, collagen fibers need to be used to replace the broken myofibers. Such misrepairs make the muscular tissue weak in functioning, and the fluid secreted by glands cannot be excreted completely. Then, the accumulation of fluid in glands increases the resistance of muscular tissue during the movements of contractions and dilations, and more and more myofibers will be broken and replaced by collagen fibers.<ref>{{cite journal | vauthors = Roehrborn CG | title = Benign prostatic hyperplasia: an overview | journal = Reviews in Urology | volume = 7 | issue = Suppl 9 | pages = S3–S14 | date = 2005 | pmid = 16985902 | pmc = 1477638 }}</ref>