Editing Autonomic nervous system (section)

====Development of the enteric nervous system====
The intricate process of enteric nervous system (ENS) development begins with the migration of cells from the vagal section of the neural crest. These cells embark on a journey from the cranial region to populate the entire gastrointestinal tract. Concurrently, the sacral section of the neural crest provides an additional layer of complexity by contributing input to the hindgut ganglia. Throughout this developmental journey, numerous receptors exhibiting tyrosine kinase activity, such as Ret and Kit, play indispensable roles. Ret, for instance, plays a critical role in the formation of enteric ganglia derived from cells known as vagal neural crest. In mice, targeted disruption of the RET gene results in renal agenesis and the absence of enteric ganglia, while in humans, mutations in the RET gene are associated with megacolon. Similarly, Kit, another receptor with tyrosine kinase activity, is implicated in Cajal interstitial cell formation, influencing the spontaneous, rhythmic, electrical excitatory activity known as slow waves in the gastrointestinal tract. Understanding the molecular intricacies of these receptors provides crucial insights into the delicate orchestration of ENS development.<ref>{{Cite journal |last1=Goyal |first1=Raj K. |last2=Hirano |first2=Ikuo |date=1996-04-25 |title=The Enteric Nervous System |url=http://dx.doi.org/10.1056/nejm199604253341707 |journal=New England Journal of Medicine |volume=334 |issue=17 |pages=1106–1115 |doi=10.1056/nejm199604253341707 |pmid=8598871 |issn=0028-4793}}</ref>