Editing Antidepressant (section)

====Social anxiety disorder====
Some antidepressants are used as a treatment for [[social anxiety disorder]], but their efficacy is not entirely convincing, as only a small proportion of antidepressants showed some effectiveness for this condition. Paroxetine was the first drug to be FDA-approved for this disorder. Its efficacy is considered beneficial, although not everyone responds favorably to the drug. Sertraline and fluvoxamine extended-release were later approved for it as well, while escitalopram is used [[Off-label use|off-label]] with acceptable efficiency. However, there is not enough evidence to support [[Citalopram]] for treating social anxiety disorder, and fluoxetine was no better than a placebo in clinical trials. [[Selective serotonin reuptake inhibitor|SSRIs]] are used as a first-line treatment for social anxiety, but they do not work for everyone. One alternative would be [[venlafaxine]], an [[Serotonin–norepinephrine reuptake inhibitor|SNRI]], which has shown benefits for social phobia in five clinical trials against a placebo, while the other SNRIs are not considered particularly useful for this disorder as many of them did not undergo testing for it. {{As of|2008}}, it is unclear if duloxetine and [[desvenlafaxine]] can provide benefits for people with social anxiety. However, another class of antidepressants called [[Monoamine oxidase inhibitor|MAOIs]] are considered effective for social anxiety, but they come with many unwanted side effects and are rarely used. [[Phenelzine]] was shown to be a good treatment option, but its use is limited by dietary restrictions. [[Moclobemide]] is a [[Reversible inhibitor of MAO-A|RIMA]] and showed mixed results, but still received approval in some European countries for social anxiety disorder. [[Tricyclic antidepressant|TCA antidepressants]], such as [[clomipramine]] and [[imipramine]], are not considered effective for this anxiety disorder in particular. This leaves out SSRIs such as paroxetine, sertraline, and fluvoxamine CR as acceptable and tolerated treatment options for this disorder.<ref>{{cite journal|vauthors=Canton J, Scott KM, Glue P|title=Optimal treatment of social phobia: systematic review and meta-analysis|journal=Neuropsychiatric Disease and Treatment|volume=8|pages=203–215|date=May 2012|pmid=22665997|pmc=3363138|doi=10.2147/NDT.S23317|doi-access=free}}</ref><ref>{{cite journal|vauthors=Hansen RA, Gaynes BN, Gartlehner G, Moore CG, Tiwari R, Lohr KN|title=Efficacy and tolerability of second-generation antidepressants in social anxiety disorder|journal=International Clinical Psychopharmacology|volume=23|issue=3|pages=170–179|date=May 2008|pmid=18408531|pmc=2657552|doi=10.1097/YIC.0b013e3282f4224a}}</ref>