Editing Antiandrogen (section)

====Scalp hair loss====
{{See also|Management of hair loss#Antiandrogens}}

5α-Reductase inhibitors like finasteride, dutasteride, and [[alfatradiol]] and the [[topical]] nonsteroidal AR antagonist [[topilutamide]] (fluridil) are approved for the treatment of pattern hair loss, also known as scalp hair loss or baldness.<ref name="TrüebLee2014">{{cite book| vauthors = Trüeb RM, Lee WS |title=Male Alopecia: Guide to Successful Management|url=https://books.google.com/books?id=0ue5BAAAQBAJ&pg=PA93|date=13 February 2014|publisher=Springer Science & Business Media|isbn=978-3-319-03233-7|pages=91–93}}</ref> This condition is generally caused by androgens, so antiandrogens can slow or halt its progression.<ref name="BologniaJorizzo">{{cite book| vauthors = Bolognia JL, Jorizzo JL, Rapini RP |title=Dermatology|year=2003 |url=https://books.google.com/books?id=f2IwYiyh3YUC&pg=PT1072|publisher=Gulf Professional Publishing|isbn=9789997638991|pages=1072–}}</ref> Systemic antiandrogens besides 5α-reductase inhibitors are not generally used to treat scalp hair loss in males due to risks like feminization (e.g., gynecomastia) and sexual dysfunction.<ref name="Simpson1989">{{cite book| vauthors = Simpson NB |title=Pharmacology of the Skin II|volume=87 / 2|year=1989|pages=495–508|issn=0171-2004|doi=10.1007/978-3-642-74054-1_37|series=Handbook of Experimental Pharmacology|isbn=978-3-642-74056-5|chapter=The Effect of Drugs on Hair|publisher=Springer }}</ref><ref name="Unger1995">{{cite book| vauthors = Unger WP |chapter=Androgenetic alopecia and its treatment. A historical overview|pages=1–33|title=Hair Transplantation | edition =Third |url=https://books.google.com/books?id=_KxsAAAAMAAJ|date=1 February 1995|publisher=Taylor & Francis|isbn=978-0-8247-9363-0}}</ref><ref name="Rasmusson1986" /><ref name="Cormanevan der Meeren1981" /><ref name="pmid19297634">{{cite journal | vauthors = Giltay EJ, Gooren LJ | title = Potential side effects of androgen deprivation treatment in sex offenders | journal = The Journal of the American Academy of Psychiatry and the Law | volume = 37 | issue = 1 | pages = 53–58 | date = 2009 | pmid = 19297634 }}</ref><ref name="LamHempstead2012">{{cite book| vauthors = Lam SM, Hempstead BR, Williams EF |title=Aesthetic Medicine|chapter=Medical Management Options for Hair Loss|year=2012|pages=529–535|publisher=Springer |doi=10.1007/978-3-642-20113-4_41|isbn=978-3-642-20112-7}}</ref><ref name="Neumann1996" /> However, they have been assessed and reported to be effective for this indication.<ref name="Simpson1989"/><ref name="Unger1995"/><ref name="Coskey1984">{{cite journal | vauthors = Coskey RJ | title = Dermatologic therapy: December, 1982, through November, 1983 | journal = Journal of the American Academy of Dermatology | volume = 11 | issue = 1 | pages = 25–52 | date = July 1984 | pmid = 6376557 | doi = 10.1016/S0190-9622(84)80163-2 }}</ref>