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== William and Mary == Soon after their accession, William and Mary rewarded John Churchill by granting him the [[Earldom of Marlborough]] and George was made [[Duke of Cumberland]]. Anne requested the use of [[Richmond Palace]] and a parliamentary allowance. William and Mary refused the first, and unsuccessfully opposed the latter, both of which caused tension between the two sisters.<ref>Green, pp. 53β54; Gregg, pp. 76β79</ref> Anne's resentment grew worse when William refused to allow George to serve in the military in an active capacity.<ref>Curtis, pp. 75β76; Green, p. 58; Gregg, p. 80</ref> The new king and queen feared that Anne's financial independence would weaken their influence over her and allow her to organise a rival political faction.<ref>Gregg, pp. 78β79</ref> From around this time,<ref>Gregg, p. 81; Somerset, p. 52</ref> at Anne's request she and Sarah Churchill, Lady Marlborough, began to call each other the pet names Mrs. Morley and Mrs. Freeman, respectively, to facilitate a relationship of greater equality between the two when they were alone.<ref>Gregg, p. 81; Somerset, p. 124</ref> In January 1692, suspecting that Marlborough was secretly conspiring with James's followers, the [[Jacobitism|Jacobites]], William and Mary dismissed him from all his offices. In a public show of support for the Marlboroughs, Anne took Sarah to a social event at the palace, and refused her sister's request to dismiss Sarah from her household.<ref>Curtis, pp. 78β80; Green, pp. 59β60; Gregg, pp. 84β87; Somerset, pp. 130β132</ref> Lady Marlborough was subsequently removed from the royal household by the [[Lord Chamberlain]], and Anne angrily left her royal lodgings and took up residence at [[Syon House]], the home of the [[Charles Seymour, 6th Duke of Somerset|Duke of Somerset]].<ref>Green, p. 62; Gregg, p. 87; Somerset, p. 132</ref> Anne was stripped of her guard of honour; courtiers were forbidden to visit her, and civic authorities were instructed to ignore her.<ref>Green, p. 62; Gregg, pp. 88β91, 96</ref> In April, Anne gave birth to a son who died within minutes. Mary visited her, but instead of offering comfort took the opportunity to berate Anne once again for her friendship with Sarah. The sisters never saw each other again.<ref>Curtis, p. 81; Green, pp. 62β63; Gregg, p. 90; Somerset, pp. 134β135</ref> Later that year, Anne moved to [[Berkeley House, London|Berkeley House]] in [[Piccadilly]], London, where she had a stillborn daughter in March 1693.<ref>Somerset, p. 146</ref> When Mary died of smallpox in 1694, William continued to reign alone. Anne became his [[heir apparent]], since any children he might have by another wife were assigned to a lower place in the line of succession, and the two reconciled publicly. He restored her previous honours, allowed her to reside in St James's Palace,<ref>Curtis, p. 84; Green, pp. 66β67; Gregg, pp. 102β103</ref> and gave her Mary's jewels,<ref>Somerset, p. 149</ref> but excluded her from government and refrained from appointing her regent during his absences abroad.<ref>Gregg, pp. 105β106; Somerset, pp. 151β152</ref> Three months later, William restored Marlborough to his offices.<ref>Gregg, p. 104</ref> With Anne's restoration at court, Berkeley House became a social centre for courtiers who had previously avoided contact with Anne and her husband.<ref>Somerset, p. 151</ref> According to James, Anne wrote to him in 1696 requesting his permission to succeed William, and thereafter promising to restore the Crown to James's line at a convenient opportunity; he declined to give his consent.<ref>Gregg, p. 108; Somerset, pp. 153β154</ref> She was probably trying to ensure her own succession by attempting to prevent a direct claim by James.<ref>Gregg, p. 122</ref> === Act of Settlement === [[File:Queen Anne and William, Duke of Gloucester by studio of Sir Godfrey Kneller.jpg|thumb|left|Anne with her son [[Prince William, Duke of Gloucester]], in a painting from the school of [[Sir Godfrey Kneller]], ''circa'' 1694]] Anne's final pregnancy ended on 25 January 1700 with a stillbirth. She had been pregnant at least 17 times over as many years, and had miscarried or given birth to stillborn children at least 12 times. Of her five liveborn children, four died before the age of two.<ref>Green, p. 335; Gregg, pp. 100, 120; Weir, pp. 268β269</ref> Anne experienced bouts of "[[gout]]" (pains in her limbs and eventually stomach and head) from at least 1698.<ref>Green, pp. 79, 336</ref> Based on her foetal losses and physical symptoms, she may have had [[systemic lupus erythematosus]],<ref name="emson">Emson, H. E. (23 May 1992). [https://www.jstor.org/stable/29715689 "For The Want Of An Heir: The Obstetrical History Of Queen Anne"], ''British Medical Journal'', vol. 304, no. 6838, pp. 1365β1366 {{Subscription required}}</ref> or [[antiphospholipid syndrome]].<ref>Somerset, pp. 80, 295</ref> Alternatively, [[pelvic inflammatory disease]] could explain why the onset of her symptoms roughly coincided with her penultimate pregnancy.<ref name=emson /><ref>Green, p. 338</ref> Other suggested causes of her failed pregnancies are [[listeriosis]],<ref>Saxbe, W. B., Jr. (January 1972). [http://pediatrics.aappublications.org/content/49/1/97 "''Listeria monocytogenes'' and Queen Anne"], ''Pediatrics'', vol. 49, no. 1, pp. 97β101</ref> [[diabetes]], [[intrauterine growth retardation]], and [[rhesus incompatibility]].<ref>Waller, p. 310</ref> Rhesus incompatibility, however, generally worsens with successive pregnancies, and so does not fit the pattern of Anne's pregnancies, as her only son to survive infancy, [[Prince William, Duke of Gloucester]], was born after a series of stillbirths.<ref>Green, pp. 337β338; Somerset, p. 79; Waller, pp. 310β311</ref> Experts also believe [[syphilis]], [[porphyria]] and pelvic deformation to be unlikely as the symptoms are incompatible with her medical history.<ref name=emson /><ref>Curtis, pp. 47β49; Green, pp. 337β338</ref> Anne's gout rendered her lame for much of her later life.<ref>Curtis, p. 84</ref> Around the court, she was carried in a [[sedan chair]], or used a wheelchair.<ref>Gregg, p. 330</ref> Around her estates, she used a one-horse [[chaise]], which she drove herself "furiously like [[Jehu]] and a mighty hunter like [[Nimrod]]".<ref>[[Jonathan Swift]] quoted in Green, pp. 101β102 and Gregg, p. 343</ref> She gained weight as a result of her sedentary lifestyle; in Sarah's words, "she grew exceeding gross and corpulent. There was something of majesty in her look, but mixed with a gloominess of soul".<ref>Green, p. 154</ref> [[Sir John Clerk, 1st Baronet]], described her in 1706: {{Blockquote |under a fit of the gout and in extreme pain and agony, and on this occasion everything about her was much in the same disorder as about the meanest of her subjects. Her face, which was red and spotted, was rendered something frightful by her negligent dress, and the foot affected was tied up with a poultice and some nasty bandages. I was much affected by this sight ...<ref>Curtis, p. 146; Green, pp. 154β155; Gregg, p. 231</ref> }} Anne's sole surviving child, the Duke of Gloucester, died at age 11 on 30 July 1700. She and her husband were "overwhelmed with grief".<ref>Luttrell, [https://archive.org/details/briefhistoricalr04lutt/page/674 vol. IV, p. 674]; Somerset, p. 163</ref> Anne ordered her household to observe a day of mourning every year on the anniversary of his death.<ref>Green, p. 80</ref> With William childless and Gloucester dead, Anne was the only person remaining in the line of succession established by the [[Bill of Rights 1689]]. To address the succession crisis and preclude a Catholic restoration, the [[Parliament of England]] enacted the [[Act of Settlement 1701]], which provided that, failing the issue of Anne and of William III by any future marriage, the Crown of England and Ireland would go to [[Sophia, Electress of Hanover]], and her Protestant descendants. Sophia was the granddaughter of [[James VI and I]] through his daughter [[Elizabeth Stuart, Queen of Bohemia|Elizabeth]], who was the sister of Anne's grandfather [[Charles I of England|Charles I]]. Over 50 Catholics with stronger claims were excluded from the line of succession.<ref>Somerset, p. 165</ref> Anne's father died in September 1701. His widow, the former queen, wrote to Anne to inform her that her father forgave her and to remind her of her promise to seek the restoration of his line, but Anne had already acquiesced to the line of succession created by the Act of Settlement.<ref>Green, pp. 86β87; Waller, p. 312</ref>
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