Editing ATPase (section)

==Classification==
There are different types of ATPases, which can differ in function (ATP synthesis and/or hydrolysis), structure (F-, V- and A-ATPases contain rotary motors) and in the type of ions they transport.

* Rotary ATPases<ref name=pmid24878343>{{cite journal | vauthors = Stewart AG, Laming EM, Sobti M, Stock D | title = Rotary ATPases--dynamic molecular machines | journal = Current Opinion in Structural Biology | volume = 25 | pages = 40–8 | date = April 2014 | pmid = 24878343 | doi = 10.1016/j.sbi.2013.11.013 | doi-access = free }} <!-- Similar 23369889 --></ref><ref>{{cite journal | vauthors = Kühlbrandt W, Davies KM | title = Rotary ATPases: A New Twist to an Ancient Machine | journal = Trends in Biochemical Sciences | volume = 41 | issue = 1 | pages = 106–116 | date = January 2016 | pmid = 26671611 | doi = 10.1016/j.tibs.2015.10.006 }}</ref>
**[[F-ATPase]]s (F1FO-ATPases) in [[mitochondria]], [[chloroplast]]s and [[bacteria]]l [[plasma membrane]]s are the prime producers of ATP, using the proton gradient generated by [[oxidative phosphorylation]] (mitochondria) or [[photosynthesis]] (chloroplasts).<ref>{{cite journal | vauthors = Watanabe R, Noji H | title = Chemomechanical coupling mechanism of F(1)-ATPase: catalysis and torque generation | journal = FEBS Letters | volume = 587 | issue = 8 | pages = 1030–1035 | date = April 2013 | pmid = 23395605 | doi = 10.1016/j.febslet.2013.01.063 }}</ref>
*** F-ATPases lacking a [[ATP synthase delta/OSCP subunit|delta/OSCP subunit]] move sodium ions instead. They are proposed to be called [[N-ATPase]]s, since they seem to form a distinct group that is further apart from usual F-ATPases than A-ATPases are from V-ATPases.<ref>{{cite journal | vauthors = Dibrova DV, Galperin MY, Mulkidjanian AY | title = Characterization of the N-ATPase, a distinct, laterally transferred Na+-translocating form of the bacterial F-type membrane ATPase | journal = Bioinformatics | volume = 26 | issue = 12 | pages = 1473–1476 | date = June 2010 | pmid = 20472544 | pmc = 2881411 | doi = 10.1093/bioinformatics/btq234 | doi-access = free }}</ref>
**[[V-ATPase]]s (V1VO-ATPases) are primarily found in eukaryotic vacuoles, catalysing ATP hydrolysis to transport solutes and lower pH in organelles like [[proton pump]] of lysosome.
**[[A-ATPase]]s (A1AO-ATPases) are found in [[Archaea]] and some extremophilic bacteria. They are arranged like V-ATPases, but function like F-ATPases mainly as ATP synthases.
**Many homologs that are not necessarily rotaty exist. See {{section link|ATP synthase|Evolution}}.
*[[P-ATPase]]s (E1E2-ATPases) are found in bacteria, fungi and in eukaryotic plasma membranes and organelles, and function to transport a variety of different ions across membranes.
*'''E-ATPases''' are [[cell-surface]] [[enzyme]]s that hydrolyze a range of NTPs, including extracellular ATP. Examples include ecto-ATPases, [[CD39]]s, and ecto-ATP/Dases, all of which are members of a "[[GDA1 CD39]]" superfamily.<ref>{{cite journal | vauthors = Knowles AF | title = The GDA1_CD39 superfamily: NTPDases with diverse functions | journal = Purinergic Signalling | volume = 7 | issue = 1 | pages = 21–45 | date = March 2011 | pmid = 21484095 | pmc = 3083126 | doi = 10.1007/s11302-010-9214-7 }}</ref>
*[[AAA proteins]] are a family of ring-shaped [[P-loop]] [[Nucleoside-triphosphatase|NTPase]]s.

===P-ATPase===
{{main|P-ATPase}}
[[P-ATPase]]s (sometime known as E1-E2 ATPases) are found in bacteria and also in eukaryotic plasma membranes and organelles. Its name is due to short time attachment of inorganic phosphate at the aspartate residues at the time of activation. Function of P-ATPase is to transport a variety of different compounds, like ions and phospholipids, across a membrane using ATP hydrolysis for energy. There are many different classes of P-ATPases, which transports a specific type of ion. P-ATPases may be composed of one or two polypeptides, and can usually take two main conformations, E1 and E2.

===Human genes===
* [[Na+/K+-ATPase|Na<sup>+</sup>/K<sup>+</sup> transporting]]: [[ATP1A1]], [[ATP1A2]], [[ATP1A3]], [[ATP1A4]], [[ATP1B1]], [[ATP1B2]], [[ATP1B3]], [[ATP1B4]]
* [[Calcium ATPase|Ca<sup>++</sup> transporting]]: [[ATP2A1]], [[ATP2A2]], [[ATP2A3]], [[ATP2B1]], [[ATP2B2]], [[ATP2B3]], [[ATP2B4]], [[ATP2C1]], [[ATP2C2]]
* [[Hydrogen potassium ATPase|H<sup>+</sup>/K<sup>+</sup> exchanging]]: [[Hydrogen potassium ATPase|ATP4A]]
* [[ATP synthase|H<sup>+</sup> transporting, mitochondrial]]: [[ATP5A1]], [[ATP5B]], [[ATP5C1]], [[ATP5C2]], [[ATP5D]], [[ATP5E]], [[ATP5F1]], [[ATP5MC1]], [[ATP5G2]], [[ATP5G3]], [[ATP5H]], [[ATP5I]], [[ATP5J]], [[ATP5J2]], [[ATP5L]], [[ATP5L2]], [[ATP5O]], [[ATP5S]], [[MT-ATP6]], [[MT-ATP8]]
* [[V-ATPase|H<sup>+</sup> transporting, lysosomal]]: [[ATP6AP1]], [[ATP6AP2]], [[ATP6V1A]], [[ATP6V1B1]], [[ATP6V1B2]], [[ATP6V1C1]], [[ATP6V1C2]], [[ATP6V1D]], [[ATP6V1E1]], [[ATP6V1E2]], [[ATP6V1F]], [[ATP6V1G1]], [[ATP6V1G2]], [[ATP6V1G3]], [[ATP6V1H]], [[ATP6V0A1]], [[ATP6V0A2]], [[ATP6V0A4]], [[ATP6V0B]], [[ATP6V0C]], [[ATP6V0D1]], [[ATP6V0D2]], [[ATP6V0E]]
* Cu<sup>++</sup> transporting: [[ATP7A]], [[ATP7B]]
* Class I, type 8: [[ATP8A1]], [[ATP8B1]], [[ATP8B2]], [[ATP8B3]], [[ATP8B4]]
* Class II, type 9: [[ATP9A]], [[ATP9B]]
* Class V, type 10: [[ATP10A]], [[ATP10B]], [[ATP10D]]
* Class VI, type 11: [[ATP11A]], [[ATP11B]], [[ATP11C]]
* H<sup>+</sup>/K<sup>+</sup> transporting, nongastric: [[ATP12A]]
* type 13: [[ATP13A1]], [[ATP13A2]], [[ATP13A3]], [[ATP13A4]], [[ATP13A5]]