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=== Vaccine === {{further|Malaria vaccine}} Given the importance of malaria, with some 220 million people infected annually, many attempts have been made to interrupt its transmission. Various methods of [[malaria prophylaxis]] have been tried including the use of [[antimalarial drug]]s to kill off the parasites in the blood, the eradication of its mosquito vectors with [[insecticide|organochlorine and other insecticides]], and the development of a [[malaria vaccine]]. All of these have proven problematic, with [[drug resistance]], [[insecticide resistance]] among mosquitoes, and repeated failure of vaccines as the parasite mutates.<ref>{{cite web |title=Malaria and Malaria Vaccine Candidates |url=https://www.historyofvaccines.org/content/articles/malaria-and-malaria-vaccine-candidates |publisher=The College of Physicians of Philadelphia |access-date=11 February 2018 |date=19 April 2017}}</ref> The first and as of 2015 the only licensed vaccine for any parasitic disease of humans is [[RTS,S]] for ''[[Plasmodium falciparum]]'' malaria.<ref name=BBC2015>{{cite news |last=Walsh |first=Fergus |author-link=Fergus Walsh |date=24 July 2015 |title=Malaria vaccine gets 'green light' |url=https://www.bbc.com/news/health-33641939?ns_mchannel=social&ns_campaign=bbc_news&ns_source=google_plus&ns_linkname=news_central |newspaper=[[BBC]] |access-date=25 July 2015}}</ref>
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